MiMeDB: Showing metabocard for L-Tryptophan (MMDBc0000170)

Plant

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:38:26 UTC

Update Date

2022-08-30 23:59:41 UTC

Metabolite ID

MMDBc0000170

Metabolite Identification

Common Name

L-Tryptophan

Description

Tryptophan is an essential amino acid that is the precursor of both serotonin and melatonin. Melatonin is a hormone that is produced by the pineal gland in animals, which regulates sleep and wakefulness. Serotonin is a brain neurotransmitter, platelet clotting factor, and neurohormone found in organs throughout the body. Metabolism of tryptophan into serotonin requires nutrients such as vitamin B6, niacin, and glutathione. Niacin (also known as vitamin B3) is an important metabolite of tryptophan. It is synthesized via kynurenine and quinolinic acids, which are products of tryptophan degradation. There are a number of conditions or diseases that are characterized by tryptophan deficiencies. For instance, fructose malabsorption causes improper absorption of tryptophan in the intestine, which reduces levels of tryptophan in the blood and leads to depression. High corn or other tryptophan-deficient diets can cause pellagra, which is a niacin-tryptophan deficiency disease with symptoms of dermatitis, diarrhea, and dementia. Hartnup's disease is a disorder in which tryptophan and other amino acids are not absorbed properly. Symptoms of Hartnup's disease include skin rashes, difficulty coordinating movements (cerebellar ataxia), and psychiatric symptoms such as depression or psychosis. Tryptophan supplements may be useful for treating Hartnup's. Assessment of tryptophan deficiency is done through studying excretion of tryptophan metabolites in the urine or blood. Blood may be the most sensitive test because the amino acid tryptophan is transported in a unique way. Increased urination of tryptophan breakdown products (such as kynurenine) correlates with increased tryptophan degradation, which occurs with oral contraception, depression, mental retardation, hypertension, and anxiety states. The requirement for tryptophan and protein decreases with age. The minimum daily requirement for adults is 3 mg/kg/day or about 200 mg a day. There is 400 mg of tryptophan in a cup of wheat germ. A cup of low fat cottage cheese contains 300 mg of tryptophan and chicken and turkey contain up to 600 mg of tryptophan per pound (http://www.dcnutrition.com). Tryptophan plays a role in "feast-induced" drowsiness. Ingestion of a meal rich in carbohydrates triggers the release of insulin. Insulin, in turn, stimulates the uptake of large neutral branched-chain amino acids (BCAAs) into muscle, increasing the ratio of tryptophan to BCAA in the bloodstream. The increased tryptophan ratio reduces competition at the large neutral amino acid transporter (which transports both BCAAs and tryptophan), resulting in greater uptake of tryptophan across the blood-brain barrier into the cerebrospinal fluid (CSF). Once in the CSF, tryptophan is converted into serotonin and the resulting serotonin is further metabolized into melatonin by the pineal gland, which promotes sleep. Under certain situations, tryptophan can be a neurotoxin and a metabotoxin. A neurotoxin is a compound that causes damage to the brain and nerve tissues. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of tryptophan can be found in glutaric aciduria type I (glutaric acidemia type I or GA1). GA1 is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine, and tryptophan due to a deficiency of mitochondrial glutaryl-CoA dehydrogenase (EC 1.3.99.7, GCDH). Excessive levels of their intermediate breakdown products (e.g. glutaric acid, glutaryl-CoA, 3-hydroxyglutaric acid, glutaconic acid) can accumulate and cause damage to the brain (and also other organs), but particularly the basal ganglia. Babies with glutaric acidemia type I are often born with unusually large heads (macrocephaly). Other symptoms include spasticity (increased muscle tone/stiffness) and dystonia (involuntary muscle contractions resulting in abnormal movement or posture), but many affected individuals are asymptomatic. High levels of tryptophan have also been implicated in eosinophilia-myalgia syndrome (EMS), an incurable and sometimes fatal flu-like neurological condition linked to the ingestion of large amounts of L-tryptophan. The risk of developing EMS increases with larger doses of tryptophan and increasing age. Some research suggests that certain genetic polymorphisms may be related to the development of EMS. The presence of eosinophilia is a core feature of EMS, along with unusually severe myalgia (muscle pain). It is thought that both tryptophan and certain unidentified tryptophan contaminants may contribute to EMS (PMID: 1763543 ). It has also been suggested that excessive tryptophan or elevation of its metabolites could play a role in amplifying some of the pathological features of EMS (PMID: 10721094 ). This pathological damage is further augmented by metabolites of the kynurenine pathway (a tryptophan degradation pathway).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI


  Mrv1652309042000142D          

 15 16  0  0  1  0            999 V2000
    0.0032   -0.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0830   -1.0830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8900   -1.2545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3025   -0.5401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7504    0.0730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0054    0.8576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1095   -0.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3644    0.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8124    1.0291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1466    0.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1466    0.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8611   -0.2625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4321   -0.2625    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4321   -1.0875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7177    0.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  5  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  7  1  0  0  0  0
  5  6  1  0  0  0  0
  6  9  2  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
 11 10  2  0  0  0  0
 12 11  1  0  0  0  0
 13 11  1  0  0  0  0
 13 14  1  1  0  0  0
 15 13  1  0  0  0  0
  1 15  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0000170

> <DATABASE_NAME>
MIME

> <SMILES>
N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1

> <INCHI_KEY>
QIVBCDIJIAJPQS-VIFPVBQESA-N

> <FORMULA>
C11H12N2O2

> <MOLECULAR_WEIGHT>
204.2252

> <EXACT_MASS>
204.089877638

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
27

> <JCHEM_AVERAGE_POLARIZABILITY>
21.047414013171778

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid

> <ALOGPS_LOGP>
-1.10

> <JCHEM_LOGP>
-1.0854569138833579

> <ALOGPS_LOGS>
-2.18

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
16.1565885064574

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.5439286383469866

> <JCHEM_PKA_STRONGEST_BASIC>
9.396082567807317

> <JCHEM_POLAR_SURFACE_AREA>
79.11

> <JCHEM_REFRACTIVITY>
56.20280000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.36e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
L-tryptophan

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  C   UNK     0       0.006  -0.490   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.155  -2.022   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0      -1.661  -2.342   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0      -2.431  -1.008   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.401   0.136   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.877   1.601   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -3.938  -0.688   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -4.414   0.777   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -3.383   1.921   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       4.007   1.820   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       4.007   0.280   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       5.341  -0.490   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       2.673  -0.490   0.000  0.00  0.00           C+0
HETATM   14  N   UNK     0       2.673  -2.030   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0       1.340   0.280   0.000  0.00  0.00           C+0
CONECT    1    2    5   15                                                  
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5    7                                                  
CONECT    5    1    4    6                                                  
CONECT    6    5    9                                                       
CONECT    7    4    8                                                       
CONECT    8    7    9                                                       
CONECT    9    6    8                                                       
CONECT   10   11                                                            
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13    1                                                       
MASTER        0    0    0    0    0    0    0    0   15    0   32    0
END

COMPND    HMDB0000929
HETATM    1  N1  UNL     1       2.923  -1.892   0.959  1.00  0.00           N  
HETATM    2  C1  UNL     1       2.034  -0.913   0.356  1.00  0.00           C  
HETATM    3  C2  UNL     1       0.836  -0.812   1.287  1.00  0.00           C  
HETATM    4  C3  UNL     1      -0.177   0.141   0.832  1.00  0.00           C  
HETATM    5  C4  UNL     1      -0.424   1.396   1.308  1.00  0.00           C  
HETATM    6  N2  UNL     1      -1.442   1.968   0.630  1.00  0.00           N  
HETATM    7  C5  UNL     1      -1.853   1.075  -0.288  1.00  0.00           C  
HETATM    8  C6  UNL     1      -2.857   1.161  -1.231  1.00  0.00           C  
HETATM    9  C7  UNL     1      -3.088   0.078  -2.082  1.00  0.00           C  
HETATM   10  C8  UNL     1      -2.333  -1.067  -1.991  1.00  0.00           C  
HETATM   11  C9  UNL     1      -1.342  -1.123  -1.044  1.00  0.00           C  
HETATM   12  C10 UNL     1      -1.086  -0.064  -0.183  1.00  0.00           C  
HETATM   13  C11 UNL     1       2.747   0.367   0.262  1.00  0.00           C  
HETATM   14  O1  UNL     1       3.918   0.458   0.664  1.00  0.00           O  
HETATM   15  O2  UNL     1       2.110   1.463  -0.275  1.00  0.00           O  
HETATM   16  H1  UNL     1       3.926  -1.608   0.900  1.00  0.00           H  
HETATM   17  H2  UNL     1       2.724  -2.038   1.978  1.00  0.00           H  
HETATM   18  H3  UNL     1       1.715  -1.262  -0.655  1.00  0.00           H  
HETATM   19  H4  UNL     1       1.245  -0.567   2.294  1.00  0.00           H  
HETATM   20  H5  UNL     1       0.413  -1.859   1.328  1.00  0.00           H  
HETATM   21  H6  UNL     1       0.110   1.869   2.106  1.00  0.00           H  
HETATM   22  H7  UNL     1      -1.865   2.909   0.751  1.00  0.00           H  
HETATM   23  H8  UNL     1      -3.464   2.063  -1.313  1.00  0.00           H  
HETATM   24  H9  UNL     1      -3.891   0.199  -2.804  1.00  0.00           H  
HETATM   25  H10 UNL     1      -2.552  -1.877  -2.675  1.00  0.00           H  
HETATM   26  H11 UNL     1      -0.758  -2.045  -0.994  1.00  0.00           H  
HETATM   27  H12 UNL     1       2.430   1.981  -1.084  1.00  0.00           H  
CONECT    1    2   16   17
CONECT    2    3   13   18
CONECT    3    4   19   20
CONECT    4    5    5   12
CONECT    5    6   21
CONECT    6    7   22
CONECT    7    8    8   12
CONECT    8    9   23
CONECT    9   10   10   24
CONECT   10   11   25
CONECT   11   12   12   26
CONECT   13   14   14   15
CONECT   15   27
END

Synonyms

Value	Source
(2S)-2-Amino-3-(1H-indol-3-yl)propanoic acid	ChEBI
(S)-alpha-Amino-1H-indole-3-propanoic acid	ChEBI
(S)-alpha-Amino-beta-(3-indolyl)-propionic acid	ChEBI
(S)-Tryptophan	ChEBI
L-(-)-Tryptophan	ChEBI
L-beta-3-Indolylalanine	ChEBI
Trp	ChEBI
Tryptophan	ChEBI
W	ChEBI
(2S)-2-Amino-3-(1H-indol-3-yl)propanoate	Generator
(S)-a-Amino-1H-indole-3-propanoate	Generator
(S)-a-Amino-1H-indole-3-propanoic acid	Generator
(S)-alpha-Amino-1H-indole-3-propanoate	Generator
(S)-Α-amino-1H-indole-3-propanoate	Generator
(S)-Α-amino-1H-indole-3-propanoic acid	Generator
(S)-a-Amino-b-(3-indolyl)-propionate	Generator
(S)-a-Amino-b-(3-indolyl)-propionic acid	Generator
(S)-alpha-Amino-beta-(3-indolyl)-propionate	Generator
(S)-Α-amino-β-(3-indolyl)-propionate	Generator
(S)-Α-amino-β-(3-indolyl)-propionic acid	Generator
L-b-3-Indolylalanine	Generator
L-Β-3-indolylalanine	Generator
(-)-Tryptophan	HMDB
(L)-Tryptophan	HMDB
(S)-1H-Indole-3-alanine	HMDB
(S)-2-Amino-3-(3-indolyl)propionic acid	HMDB
(S)-a-Amino-b-indolepropionate	HMDB
(S)-a-Amino-b-indolepropionic acid	HMDB
(S)-a-Aminoindole-3-propionate	HMDB
(S)-a-Aminoindole-3-propionic acid	HMDB
(S)-alpha-Amino-beta-indolepropionate	HMDB
(S)-alpha-Amino-beta-indolepropionic acid	HMDB
(S)-alpha-Aminoindole-3-propionate	HMDB
(S)-alpha-Aminoindole-3-propionic acid	HMDB
1-beta-3-Indolylalanine	HMDB
1beta-3-Indolylalanine	HMDB
1H-Indole-3-alanine	HMDB
2-Amino-3-indolylpropanoate	HMDB
2-Amino-3-indolylpropanoic acid	HMDB
3-(1H-indol-3-yl)-L-Alanine	HMDB
3-indol-3-Ylalanine	HMDB
Alpha'-amino-3-indolepropionic acid	HMDB
alpha-Aminoindole-3-propionic acid	HMDB
Ardeytropin	HMDB
H-TRP-OH	HMDB
Indole-3-alanine	HMDB
Kalma	HMDB
L-alpha-Amino-3-indolepropionic acid	HMDB
L-alpha-Aminoindole-3-propionic acid	HMDB
L-Tryptofan	HMDB
L-Tryptophane	HMDB
Lopac-T-0254	HMDB
Lyphan	HMDB
Optimax	HMDB
Pacitron	HMDB
Sedanoct	HMDB
Triptofano	HMDB
Trofan	HMDB
Tryptacin	HMDB
Tryptan	HMDB
Tryptophane	HMDB
Tryptophanum	HMDB
Ardeydorm	HMDB
L Tryptophan	HMDB
L-Tryptophan-ratiopharm	HMDB
Merck brand OF tryptophan	HMDB
Niddapharm brand OF tryptophan	HMDB
ICN brand OF tryptophan	HMDB
Levotryptophan	HMDB
PMS Tryptophan	HMDB
PMS-Tryptophan	HMDB
Ratiopharm brand OF tryptophan	HMDB
Esparma brand OF tryptophan	HMDB
Ratio-tryptophan	HMDB
L Tryptophan ratiopharm	HMDB
Naturruhe	HMDB
Tryptophan metabolism alterations	HMDB
Ardeypharm brand OF tryptophan	HMDB
Kalma brand OF tryptophan	HMDB
Pharmascience brand OF tryptophan	HMDB
Upsher-smith brand OF tryptophan	HMDB
Ratio tryptophan	HMDB

Molecular Formula

C₁₁H₁₂N₂O₂

Average Mass

204.2252

Monoisotopic Mass

204.089877638

IUPAC Name

(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid

Traditional Name

L-tryptophan

CAS Registry Number

73-22-3

SMILES

N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

InChI Identifier

InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1

InChI Key

QIVBCDIJIAJPQS-VIFPVBQESA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. Indolyl carboxylic acids and derivatives are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Indolyl carboxylic acids and derivatives

Direct Parent

Indolyl carboxylic acids and derivatives

Alternative Parents

Substituents

Indolyl carboxylic acid derivative
Alpha-amino acid
Alpha-amino acid or derivatives
L-alpha-amino acid
3-alkylindole
Indole
Aralkylamine
Benzenoid
Substituted pyrrole
Heteroaromatic compound
Pyrrole
Amino acid or derivatives
Amino acid
Carboxylic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Azacycle
Amine
Primary aliphatic amine
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Organonitrogen compound
Organooxygen compound
Primary amine
Organopnictogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:16828 )
L-alpha-amino acid (CHEBI:16828 )
tryptophan (CHEBI:16828 )
erythrose 4-phosphate/phosphoenolpyruvate family amino acid (CHEBI:16828 )
Common amino acids (C00078 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	1.36 g/L	ALOGPS
logP	-1.1	ALOGPS
logP	-1.1	ChemAxon
logS	-2.2	ALOGPS
pKa (Strongest Acidic)	2.54	ChemAxon
pKa (Strongest Basic)	9.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	79.11 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	56.2 m³·mol⁻¹	ChemAxon
Polarizability	21.05 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Extracellular

Biospecimen Locations

Blood
Breast Milk
Cerebrospinal Fluid (CSF)
Feces
Fibroblasts
Neuron
Placenta
Prostate
Saliva
Sweat
Urine

Tissue Locations

Fibroblasts
Neuron
Placenta
Prostate

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191948	Aromatic-L-amino-acid decarboxylase	Enzyme	P20711	Homo_sapiens
MMDBp0192103	Indoleamine 2,3-dioxygenase 1	Unknown	P14902	Homo_sapiens
MMDBp0192127	Tryptophan 5-hydroxylase 1	Enzyme	P17752	Homo_sapiens
MMDBp0192129	Tryptophan 5-hydroxylase 2	Enzyme	Q8IWU9	Homo_sapiens
MMDBp0192218	Tryptophan--tRNA ligase, cytoplasmic	Enzyme	P23381	Homo_sapiens
MMDBp0192268	Tryptophan--tRNA ligase, mitochondrial	Enzyme	Q9UGM6	Homo_sapiens
MMDBp0192717	Monocarboxylate transporter 8	Transporter	P36021	Homo_sapiens
MMDBp0194001	Monocarboxylate transporter 10	Transporter	Q8TF71	Homo_sapiens
MMDBp0194007	Tryptophan 2,3-dioxygenase	Unknown	P48775	Homo_sapiens
MMDBp0194191	Indoleamine 2,3-dioxygenase 2	Unknown	Q6ZQW0	Homo_sapiens
MMDBp0195052	L-amino-acid oxidase	Unknown	Q96RQ9	Homo_sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank
Anti-inflammatory pathway
Immunometabolism Pathway (Bacterial Activation)
Immunometabolism Pathway (Viral Activation)
Metabolism and Physiological Effects of Indoxyl Sulfate
Protein Synthesis: Tryptophan

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Alzheimer's disease		Association	Human Saliva	HMDB	23857558
Alzheimer's disease	Decreased	Association	Human Urine	HMDB	17031479
Alzheimer's disease	Decreased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	17031479
Alzheimer's disease	Decreased	Association	Human Blood	HMDB	17031479
Cachexia	Slight Decrease	Association	Human Urine	HMDB	18953024
Celiac disease		Association	Human Cerebrospinal Fluid (CSF)	HMDB	6182788
Epilepsy		Association	Human Cerebrospinal Fluid (CSF)	HMDB	1705463
Epilepsy	Decreased	Association	Human Blood	HMDB	14992292
Friedreich's ataxia		Association	Human Cerebrospinal Fluid (CSF)	HMDB	11383938
Frontotemporal dementia		Association	Human Saliva	HMDB	23857558
Hartnup disease	Decreased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	2472426
Hereditary spastic paraplegia	Decreased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	11383938
Hypothyroidism	Decreased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	9849813
Leukemia		Association	Human Cerebrospinal Fluid (CSF)	HMDB	15911239
Olivopontocerebral atrophy		Association	Human Cerebrospinal Fluid (CSF)	HMDB	11383938
Schizophrenia	Increased	Association	Human Blood	HMDB	25004141
Schizophrenia		Association	Human Cerebrospinal Fluid (CSF)	HMDB	7595563
Schizophrenia		Association	Human Blood	HMDB	19390223
Schizophrenia	Slight Increase	Association	Human Blood	HMDB	2480613
Sepsis	Decreased	Association	Human Blood	HMDB	26847922
Eosinophilic esophagitis		Association	Human Urine	HMDB	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Obesity		Association	Human Blood	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Obesity		Association	Human Blood	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Alzheimer's Disease	decreased	Association	Human plasma	PubMed	33269100

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	657	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human feces; pleural fluid plaque; bal; Cattle ; River trout ; Sheep ; Chicken	Microbial culture; Metabolic reconstruction
Bacteria	Firmicutes	693	Human ; Human vaginal secretion; Human feces; Human pleural fluid plaque; Pig ; Cattle ; Catfish	Microbial culture; Metabolic reconstruction
Eukaryota/Fungi	Ascomycota	28	Human feces	Microbial culture; Unknown
Bacteria	Fusobacteria	38	Human feces; Human	Microbial culture; Metabolic reconstruction
Bacteria	Bacteroidetes	201	Human feces; Human ; Human appendix biopsy	Microbial culture; Metabolic reconstruction
Bacteria	Fibrobacteres	1		Microbial culture
Bacteria	Actinobacteria	267	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Cattle	Metabolic reconstruction
Bacteria	Verrucomicrobia	2	Human ; Human feces	Metabolic reconstruction
Bacteria	Synergistetes	6	Human feces	Metabolic reconstruction
Bacteria	Spirochaetes	8	Human feces; Human	Metabolic reconstruction
Archaea	Thaumarchaeota	2	Human feces	Metabolic reconstruction
Archaea	Euryarchaeota	11	Human feces; Cattle ; Human	Metabolic reconstruction
Bacteria	Candidatus Melainabacteria	2	Human feces	Metabolic reconstruction
Bacteria	Tenericutes	8	Human feces	Metabolic reconstruction
Bacteria	Planctomycetes	2	Human feces	Metabolic reconstruction
Archaea	Crenarchaeota	2	Human feces	Metabolic reconstruction
Eukaryota/Fungi	Basidiomycota	4	Human feces
Bacteria	Cyanobacteria	31	Human
Archaea/Archaea	Crenarchaeota	7	Human feces	Metabolic reconstruction
Bacteria	Aquificae	2
Archaea/Archaea	Euryarchaeota	30	Human feces; Cattle ; Human	Metabolic reconstruction
Bacteria/NULL	Proteobacteria	5	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human feces; pleural fluid plaque; bal; Cattle ; River trout ; Sheep ; Chicken	Microbial culture; Metabolic reconstruction
Bacteria	Chloroflexi	9
Bacteria	Chlorobi	10
Bacteria	Chlamydiae	3	Cat ; Human
Bacteria	Deinococcus-Thermus	3
Bacteria	Dictyoglomi	2
Bacteria	Thermotogae	8
Bacteria	Acidobacteria	2
Bacteria	nah	1
Bacteria	Elusimicrobia	1

Exposure Sources

Food Exposures

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified								HMDB
Human	Detected and Quantified	0.22	0.16			Adult (>18 years old)	Male	Alzheimer's disease	HMDB	23857558
Human	Detected and Quantified	1.19	0.23			Adult (>18 years old)	Both	Alzheimer's disease	HMDB	17031479
Human	Detected and Quantified	1.3	0.32			Adult (>18 years old)	Both	Alzheimer's disease	HMDB	17031479
Human	Detected and Quantified	33.06	8.99			Adult (>18 years old)	Both	Alzheimer's disease	HMDB	17031479
Human	Detected and Quantified	7.83	7.48			Adult (>18 years old)	Both	Cachexia	HMDB	18953024
Human	Detected and Quantified	2.035	0.649			Adult (>18 years old)	Not Specified	celiac disease	HMDB	6182788
Human	Detected and Quantified	1.6	0.57			Adult (>18 years old)	Both	Epilepsy	HMDB	1705463
Human	Detected and Quantified	1.68	0.52			Adult (>18 years old)	Both	Epilepsy	HMDB	1705463
Human	Detected and Quantified	1.7	0.27			Adult (>18 years old)	Both	Epilepsy	HMDB	1705463
Human	Detected and Quantified	1.7	0.4			Adult (>18 years old)	Not Specified	Epilepsy	HMDB	1705463
Human	Detected and Quantified	11.5	8.2			Adult (>18 years old)	Not Specified	Epilepsy	HMDB	1705463
Human	Detected and Quantified	14.3	12.5			Adult (>18 years old)	Not Specified	Epilepsy	HMDB	1705463
Human	Detected and Quantified	31.6		29.6	33.6	Adult (>18 years old)	Both	Epilepsy	HMDB	14992292
Human	Detected and Quantified	37.2		34.3	40.1	Adult (>18 years old)	Both	Epilepsy	HMDB	14992292
Human	Detected and Quantified	53.3		50.3	56.3	Adult (>18 years old)	Both	Epilepsy	HMDB	14992292
Human	Detected and Quantified	2.4	0.13			Not Specified	Not Specified	Friedreich's ataxia	HMDB	11383938
Human	Detected and Quantified	0.40	0.21			Adult (>18 years old)	Male	Frontotemporal lobe dementia	HMDB	23857558
Human	Detected and Quantified	1.0	0.2			Children (1-13 years old)	Both	Hartnup Disease	HMDB	2472426
Human	Detected and Quantified	1.80	0.2			Adult (>18 years old)	Not Specified	Autosomal recessive spastic ataxia of Charlevoix-Saguena	HMDB	11383938
Human	Detected and Quantified	0.0018	0.0003			Adult (>18 years old)	Both	Hypothyroidism	HMDB	9849813
Human	Detected and Quantified	1.6	0.3			Adult (>18 years old)	Both	Hypothyroidism	HMDB	9849813
Human	Detected and Quantified	1.8	0.3			Adult (>18 years old)	Not Specified	Hypothyroidism	HMDB	9849813
Human	Detected and Quantified	12.8	3.5			Children (1-13 years old)	Not Specified	Leukemia	HMDB	15911239
Human	Detected and Quantified	13.0	5.2			Children (1-13 years old)	Not Specified	Leukemia	HMDB	15911239
Human	Detected and Quantified	0.60	0.49			Adult (>18 years old)	Both	Lewy body disease	HMDB	23857558
Human	Detected and Quantified	63.6				Infant (0-1 year old)	Female	Nicotinamide Adenine Dinucleotide Deficiency	HMDB	28792876
Human	Detected and Quantified	2.42	0.14			Adult (>18 years old)	Not Specified	Olivopontocerebellar atrophy (OPCA)	HMDB	11383938
Human	Detected and Quantified	101	4.48			Adult (>18 years old)	Both	Schizophrenia	HMDB	25004141
Human	Detected and Quantified	2.67	0.6			Adult (>18 years old)	Both	Schizophrenia	HMDB	7595563
Human	Detected and Quantified	63.51	2.04			Adult (>18 years old)	Both	Schizophrenia	HMDB	19390223
Human	Detected and Quantified	80.2	22.0			Adult (>18 years old)	Female	Schizophrenia	HMDB	2480613
Human	Detected and Quantified	83.3	26.0			Adult (>18 years old)	Male	Schizophrenia	HMDB	2480613
Human	Detected and Quantified	27.2		8.3	35	Adult (>18 years old)	Both	Sepsis	HMDB	26847922
Human	Detected and Quantified			10.707	21.382	Children (1-13 years old)	Female	Tryptophanuria with dwarfism	HMDB	14055140
Human	Detected and Quantified	2.3				Children (1-13 years old)	Both	Normal	HMDB	2472426
Human	Detected and Quantified	3.9				Adult (>18 years old)	Both	Normal	HMDB	21388201
Human	Detected and Quantified	7.8				Adult (>18 years old)	Both	Normal	HMDB	19309105
Human	Detected and Quantified	< 10				Adult (60 years old)	Male	Normal	HMDB	22194922
Human	Detected and Quantified	< 10				Adult (40 years old)	Male	Normal	HMDB	22194922
Human	Detected and Quantified			0.45	15.92	Newborn (0-30 days old)	Male	Normal	HMDB	25536744
Human	Detected and Quantified	0.46	0.31			Adult (>18 years old)	Female	Normal	HMDB	23857558
Human	Detected and Quantified	0.5	0.5			Adult (>18 years old)	Both	Normal	HMDB	15995595
Human	Detected and Quantified			1.21	72.48	Newborn (0-30 days old)	Female	Normal	HMDB	25536744
Human	Detected and Quantified			1.86	6.03	Newborn (0-30 days old)	Both	Normal	HMDB	32340350
Human	Detected and Quantified			10	40	Infant (0-1 year old)	Both	Normal	HMDB	30830347
Human	Detected and Quantified	11.48	16.66			Newborn (0-30 days old)	Female	Normal	HMDB	25536744
Human	Detected and Quantified	13.52	7.37			Infant (0-1 year old)	Both	Normal	HMDB	2026685
Human	Detected and Quantified	15.9	4.1			Adult (>18 years old)	Not Specified	Normal	HMDB	22546835
Human	Detected and Quantified	170	110			Adult (>18 years old)	Both	Normal	HMDB	27624970
Human	Detected and Quantified	2.0		1.2	2.5	Adult (>18 years old)	Not Specified	Normal	HMDB	2580417
Human	Detected and Quantified	2.0	0.53			Adult (>18 years old)	Not Specified	Normal	HMDB	11383938
Human	Detected and Quantified	2.25	0.95			Adult (>18 years old)	Not Specified	Normal	HMDB	6182788
Human	Detected and Quantified	2.32	0.09			Adult (>18 years old)	Not Specified	Normal	HMDB	1422788
Human	Detected and Quantified	2.64	0.52			Adult (>18 years old)	Both	Normal	HMDB	7595563
Human	Detected and Quantified	20	20			Adult (>18 years old)	Both	Normal	HMDB	27624970
Human	Detected and Quantified	20.35	22.61			Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human	Detected and Quantified	20.4	8.2			Adult (>18 years old)	Both	Normal	HMDB	15911239
Human	Detected and Quantified	23.74	31.66			Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human	Detected and Quantified	26.00	32.79			Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human	Detected and Quantified	3.2	1.3			Adult (>18 years old)	Female	Normal	HMDB	24027187
Human	Detected and Quantified	3.22	0.97			Newborn (0-30 days old)	Female	Normal	HMDB	32340350
Human	Detected and Quantified	3.44	0.99			Newborn (0-30 days old)	Male	Normal	HMDB	32340350
Human	Detected and Quantified			3.6	6.2	Adult (>18 years old)	Female	Normal	HMDB	27012787
Human	Detected and Quantified	36.5		20.6	51.8	Children (1-13 uears old)	Both	Normal	HMDB	27294788
Human	Detected and Quantified	4.0	3.9			Newborn (0-30 days old)	Male	Normal	HMDB	25536744
Human	Detected and Quantified			4.4	6.9	Adult (>18 years old)	Male	Normal	HMDB	27012787
Human	Detected and Quantified	44.0		37.0	51.0	Adult (>18 years old)	Both	Normal	HMDB	12297216
Human	Detected and Quantified	5	3			Adult (>18 years old)	Both	Normal	HMDB	18502700
Human	Detected and Quantified	5.6		2.1	9.3	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human	Detected and Quantified	54.5	9.7			Adult (>18 years old)	Both	Normal	HMDB	21359215
Human	Detected and Quantified	6.3		3.4	11.1	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human	Detected and Quantified	63.0	10.7			Adult (>18 years old)	Both	Normal	HMDB	28278231
Human	Detected and Quantified	69.71	0.99			Adult (>18 years old)	Both	Normal	HMDB	19390223
Human	Detected and Quantified	7.377		3.917	12.274	Children (1-13 years old)	Not Specified	Normal	HMDB	14055140
Human	Detected and Quantified	73.9		63	87	Infant (0-1 year old)		Normal	HMDB	25754623
Human	Detected and Quantified	78.4	15.5			Adult (>18 years old)	Both	Normal	HMDB	21359215
Human	Detected and Quantified	81.3	3.36			Adult (>18 years old)	Both	Normal	HMDB	25004141
Human	Detected and Quantified	87.4		75.6	98.6	Newborn (0-30 days old)		Normal	HMDB	25754623
Human	Detected and Quantified	9.57	7.27			Children (0-2 years old)	Male	Normal	HMDB	25536744
Human	Detected and Quantified	9.85	6.69			Children (0-2 years old)	Female	Normal	HMDB	25536744
Human	Detected and Quantified	12.011	6.328			Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human	Detected and Quantified	76.2	15.4			Children (1-13 years old)	Both	Obesity	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Human	Detected and Quantified	84.6	16.7			Children (1-13 years old)	Both	Obesity	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Human	Detected and Quantified	11.931	6.642			Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human	Detected and Quantified			0.5	8	Children (0 - 10 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			0.5	9	Adolescent (>11 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			18	55	Newborn (0-30 days old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			2.04	14.02	Adult (>21 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			2.04	21.03	Newborn (0-30 days old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			2.04	27.02	Children (2 - 4 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			2.04	27.02	Children (4 - 13 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			2.04	27.02	Adolescent (13 - 21 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			21	80	Children (3 months - 6 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			25	70	Children (6 - 18 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			25	80	Infant (1 - 3 months old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			4.97	46.02	Infant (1 - 6 months old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			4.97	46.02	Infant (6 months - <1 year old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			4.97	46.02	Children (1 - 2 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human	Detected and Quantified			2.45	29.40	Adult (>18 years old)	Both	Normal	HMDB	David F. Putnam Composition and Concentrative Properties of Human Urine. NASA Contractor Report. July 1971
Human	Detected and Quantified	0.96	8.83			Children (1 - 13 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	1.18	1.15			Children (1 - 13 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	1.3	0.4			Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	101.5	27.2			Newborn (0-30 days old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	45.0	9.0			Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	48.7	11.6			Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	4.62				Adult (>18 years old)	Both	Normal	HMDB	Shaykhutdinov RA, MacInnis GD, Dowlatabadi R, Weljie AM, Vogel HJ. Quantitative analysis of metabolite concentrations in human urine samples using 13C{1H} NMR spectroscopy. Metabolomics. 2009
Human	Detected and Quantified	4.80	3.41			Adult (>18 years old)	Both	Normal	HMDB	https://doi.org/10.1007/s11306-015-0840-5
Human	Detected and Quantified			40.0	95.0	Adult (>18 years old)	Both	Normal	HMDB	Molecular You (https://molecularyou.com)
Human	Detected and Quantified			1.13	34.27	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human	Detected and Quantified			1.13	34.27	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human	Detected and Quantified			1.58	35.63	Infant (0-1 year old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human	Detected and Quantified			1.58	35.63	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human	Detected and Quantified			1.70	25.90	Adolescent (13-18 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human	Detected and Quantified			2.036	12.90	Adult (>18 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Fibroblasts	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597
Human Neuron	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597
Human Placenta	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597
Human Prostate	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597
Human Urine	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	20300169
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified					Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	18052033
Human Feces	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	19573517
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	21761941
Human Feces	Detected but not Quantified					Children (1-13 years old)	Not Specified	Normal	HMDB	21970810
Human Blood	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	19678709
Human Feces	Detected but not Quantified					Adult (>18 years old)	Female	Normal	HMDB	26709303
Human Blood	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	22007635
Human Feces	Detected but not Quantified					Children (1-13 years old)	Both	Normal	HMDB	21970810
Human Feces	Detected but not Quantified					Children (1-13 years old)	Both	Normal	HMDB	24130822
Human Feces	Detected but not Quantified					Children (1-13 years old)	Not Specified	Normal	HMDB	27452636
Human Feces	Detected but not Quantified					Children (6 - 18 years old)	Both	Normal	HMDB	27609529
Human Feces	Detected but not Quantified					Children (6 - 18 years old)	Not Specified	Normal	HMDB	27609529
Human Sweat	Detected but not Quantified					Adult	Both	Normal	HMDB	26755145
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified					Adult (>18 years old)	Not Specified	Normal	HMDB	25985090
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Urine	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Blood	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	32966057

External Links

HMDB ID

HMDB0000929

DrugBank ID

DB00150

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

16828

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

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Showing metabocard for L-Tryptophan (MMDBc0000170)

MOL for #<Metabolite:0x00007f12206e02b0>

3D MOL for #<Metabolite:0x00007f12206e02b0>

3D SDF for #<Metabolite:0x00007f12206e02b0>

3D-SDF for #<Metabolite:0x00007f12206e02b0>

PDB for #<Metabolite:0x00007f12206e02b0>

3D PDB for #<Metabolite:0x00007f12206e02b0>

SMILES for #<Metabolite:0x00007f12206e02b0>

INCHI for #<Metabolite:0x00007f12206e02b0>

Structure for #<Metabolite:0x00007f12206e02b0>

3D Structure for #<Metabolite:0x00007f12206e02b0>