MiMeDB: Showing metabocard for Raffinose (MMDBc0000229)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:40:35 UTC

Update Date

2022-08-31 00:15:47 UTC

MiMeDB ID

MMDBc0000229

Metabolite Identification

Common Name

Raffinose

Description

Raffinose is a complex carbohydrate. It is a trisaccharide composed of galactose, fructose, and glucose. It can be found in beans, cabbage, brussels sprouts, broccoli, asparagus, other vegetables, and whole grains. Raffinose is hydrolyzed to D-galactose and sucrose by D-galactosidase (D-GAL). D-GAL also hydrolyzes other D-galactosides such as stachyose, verbascose, and galactinol [1-O-(D-galactosyl)-myoinositol], if present. The enzyme does not cleave linked galactose, as in lactose. Raffinose is also known as melitose and may be thought of as galactose and sucrose connected via an alpha(1->6) glycosidic linkage. Thus, raffinose can be broken down into galactose and sucrose via the enzyme alpha-galactosidase. Human intestines do not contain this enzyme (Wikipedia). Raffinose is a trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal (PubChem).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₁₈H₃₂O₁₆

Average Molecular Weight

504.4371

Monoisotopic Molecular Weight

504.169034976

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

512-69-6

SMILES

Not Available

InChI Identifier

InChI=1S/C18H32O16/c19-1-5-8(22)11(25)13(27)16(31-5)30-3-7-9(23)12(26)14(28)17(32-7)34-18(4-21)15(29)10(24)6(2-20)33-18/h5-17,19-29H,1-4H2/t5-,6-,7-,8+,9-,10-,11+,12+,13-,14-,15+,16+,17-,18+/m1/s1

InChI Key

MUPFEKGTMRGPLJ-ZQSKZDJDSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Blood
Feces
Platelet

Tissue Locations

Platelet

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76e1a0060>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Firmicutes	349	Human ; Human Unknown; Human Feces; Pig ; Cattle	Microbial culture; Metabolic reconstruction
	Bacteroidetes	129	Human ; Human Feces; Human Appendix biopsy	Microbial culture; Metabolic reconstruction
	Spirochaetes	3	Human Feces	Microbial culture; Metabolic reconstruction
	Actinobacteria	80	Human Feces; Human	Microbial culture; Metabolic reconstruction
	Proteobacteria	75	Human ; Human Feces; Pig	Microbial culture; Metabolic reconstruction
	Fusobacteria	7	Human ; Human Feces	Microbial culture; Metabolic reconstruction
	Deinococcus-Thermus	1		Microbial culture
	Chloroflexi	1		Microbial culture
Fungi	Ascomycota	1	Human Feces	Microbial culture
	Verrucomicrobia	1	Human	Metabolic reconstruction
	Crenarchaeota	1	Human Feces	Metabolic reconstruction

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified						HMDB		details
Human	Detected and Quantified	4.8	5.4	Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human Platelet	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Feces	Detected but not Quantified			Infant (0-1 year old)	Both	Normal	HMDB	28701177	details

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Gundermann KJ, Lie TS: Problems of competition in charcoal hemoperfusion for the treatment of intoxications. Artif Organs. 1979 Nov;3(4):346-9. doi: 10.1111/j.1525-1594.1979.tb01075.x. [PubMed:533425 ]
Gross KC, Houghton MP, Senterfit LB: Presumptive speciation of Streptococcus bovis and other group D streptococci from human sources by using arginine and pyruvate tests. J Clin Microbiol. 1975 Jan;1(1):54-60. doi: 10.1128/jcm.1.1.54-60.1975. [PubMed:1176592 ]
Persson AE, Schnermann J, Agerup B, Eriksson NE: The hydraulic conductivity of the rat proximal tubular wall determined with colloidal solutions. Pflugers Arch. 1975 Oct 16;360(1):25-44. doi: 10.1007/BF00584324. [PubMed:1237863 ]
Lobley RW, Burrows PC, Warwick R, Dawson DJ, Holmes R: Simultaneous assessment of intestinal permeability and lactose tolerance with orally administered raffinose, lactose and L-arabinose. Clin Sci (Lond). 1990 Aug;79(2):175-83. doi: 10.1042/cs0790175. [PubMed:2167807 ]
Horodniceanu T, Delbos F: [Group D streptococci in human infections: identification and sensitivity to antibiotics (author's transl)]. Ann Microbiol (Paris). 1980 Sep-Oct;131B(2):131-44. [PubMed:7458116 ]
Xue S, Paterson W, Valdez D, Miller D, Christoff B, Wong LT, Diamant NE: Effect of an o-raffinose cross-linked haemoglobin product on oesophageal and lower oesophageal sphincter motor function. Neurogastroenterol Motil. 1999 Dec;11(6):421-30. doi: 10.1046/j.1365-2982.1999.00171.x. [PubMed:10583849 ]
Lieberthal W, Fuhro R, Alam H, Rhee P, Szebeni J, Hechtman HB, Favuzza J, Veech RL, Valeri CR: Comparison of the effects of a 50% exchange-transfusion with albumin, hetastarch, and modified hemoglobin solutions. Shock. 2002 Jan;17(1):61-9. doi: 10.1097/00024382-200201000-00011. [PubMed:11795671 ]
Toussaint M, Latger-Cannard V, Caron A, Lecompte T, Vigneron C, Menu P: Hemoglobin-based oxygen carriers do not alter platelet functions: study of three chemically modified hemoglobin solutions. Intensive Care Med. 2003 Jan;29(1):62-8. doi: 10.1007/s00134-002-1558-1. Epub 2002 Nov 30. [PubMed:12528024 ]
Hessels J, Snoeyink EJ, Platenkamp AJ, Voortman G, Steggink J, Eidhof HH: Assessment of intestinal permeability: enzymatic determination of urinary mannitol, raffinose, sucrose and lactose on Hitachi analyzer. Clin Chem Lab Med. 2003 Jan;41(1):33-8. doi: 10.1515/CCLM.2003.007. [PubMed:12636047 ]
Rodrigues Silva C, Dutra de Oliveira JE, de Souza RA, Silva HC: Effect of a rice bran fiber diet on serum glucose levels of diabetic patients in Brazil. Arch Latinoam Nutr. 2005 Mar;55(1):23-7. [PubMed:16187674 ]

Showing metabocard for Raffinose (MMDBc0000229)

MOL for #<Metabolite:0x000055b76e0a8d88>

3D MOL for #<Metabolite:0x000055b76e0a8d88>

3D SDF for #<Metabolite:0x000055b76e0a8d88>

3D-SDF for #<Metabolite:0x000055b76e0a8d88>

PDB for #<Metabolite:0x000055b76e0a8d88>

3D PDB for #<Metabolite:0x000055b76e0a8d88>

SMILES for #<Metabolite:0x000055b76e0a8d88>

INCHI for #<Metabolite:0x000055b76e0a8d88>

Structure for #<Metabolite:0x000055b76e0a8d88>

3D Structure for #<Metabolite:0x000055b76e0a8d88>