MiMeDB: Showing metabocard for Cer(d18:1/16:0) (MMDBc0000607)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-12-10 18:50:59 UTC

Update Date

2022-08-31 06:10:17 UTC

MiMeDB ID

MMDBc0000607

Metabolite Identification

Common Name

Cer(d18:1/16:0)

Description

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₃₄H₆₇NO₃

Average Molecular Weight

537.9007

Monoisotopic Molecular Weight

537.512095015

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C34H67NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,32-33,36-37H,3-26,28,30-31H2,1-2H3,(H,35,38)/b29-27+/t32-,33+/m0/s1

InChI Key

YDNKGFDKKRUKPY-TURZORIXSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Blood
Brain
Epidermis
Feces
Fibroblasts
Intestine
Kidney
Liver
Neuron
Pancreas
Placenta
Platelet
Skeletal Muscle
Spleen
Testis
Thyroid Gland
Urine

Tissue Locations

Brain
Epidermis
Fibroblasts
Intestine
Kidney
Liver
Neuron
Pancreas
Placenta
Platelet
Skeletal Muscle
Spleen
Testis
Thyroid Gland

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76e02f708>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Bacteroidetes	12	Human ; Human Feces	Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
	Actinobacteria	19	Human Feces; Human	Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction;
	Firmicutes	124	Human Feces; Human	Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
	Proteobacteria	58	Human ; Human Feces	Metabolic reconstruction
	Verrucomicrobia	1	Human	Metabolic reconstruction
	Fusobacteria	1	Human Feces	Metabolic reconstruction
	Synergistetes	2	Human Feces	Metabolic reconstruction
	Euryarchaeota	2	Human Feces	Metabolic reconstruction
	Planctomycetes	1	Human Feces	Metabolic reconstruction
	Spirochaetes	1	Human Feces	Metabolic reconstruction
	Thaumarchaeota	1	Human Feces	Metabolic reconstruction
	Candidatus Melainabacteria	1	Human Feces	Metabolic reconstruction
Fungi	Ascomycota	1

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Age	Sex	Health Condition	Data Source	Reference
Human	Detected and Quantified	0.008	0.001	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.012	0.001	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.022	0.001	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.036	0.002	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.040	0.002	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.061	0.0007	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.128	0.012	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.145	0.007	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.271	0.013	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.281	0.033	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.331	0.029	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	1.00	0.029	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	1.22	0.046	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	3.00	0.107	Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human Brain	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Epidermis	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Fibroblasts	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Intestine	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Kidney	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Liver	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Neuron	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Pancreas	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Placenta	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Platelet	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Skeletal Muscle	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Spleen	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Testis	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Thyroid Gland	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Feces	Detected but not Quantified			Adult (>18 years old)	Both	Normal	HMDB	29808030	details
Human Urine	Detected but not Quantified			Adult (>18 years old)	Both	Normal	HMDB	32966057	details
Human Blood	Detected but not Quantified			Adult (>18 years old)	Both	Normal	HMDB	32966057	details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Bowser PA, Gray GM: Sphingomyelinase in pig and human epidermis. J Invest Dermatol. 1978 Jun;70(6):331-5. doi: 10.1111/1523-1747.ep12543516. [PubMed:25935 ]
Dunn HG, Dolman CL, Farrell DF, Tischler B, Hasinoff C, Woolf LI: Krabbe's leukodystrophy without globoid cells. Neurology. 1976 Nov;26(11):1035-41. doi: 10.1212/wnl.26.11.1035. [PubMed:988509 ]
Ogawa-Goto K, Funamoto N, Abe T, Nagashima K: Different ceramide compositions of gangliosides between human motor and sensory nerves. J Neurochem. 1990 Nov;55(5):1486-93. doi: 10.1111/j.1471-4159.1990.tb04930.x. [PubMed:2213006 ]
Ogawa-Goto K, Ohta Y, Kubota K, Funamoto N, Abe T, Taki T, Nagashima K: Glycosphingolipids of human peripheral nervous system myelins isolated from cauda equina. J Neurochem. 1993 Oct;61(4):1398-403. doi: 10.1111/j.1471-4159.1993.tb13633.x. [PubMed:7690848 ]
Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM: The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest. 1995 May;95(5):2281-90. doi: 10.1172/JCI117919. [PubMed:7738193 ]
Marchesini S, Demasi L, Cestone P, Preti A, Agmon V, Dagan A, Navon R, Gatt S: Sulforhodamine GM1-ganglioside: synthesis and physicochemical properties. Chem Phys Lipids. 1994 Aug 8;72(2):143-52. doi: 10.1016/0009-3084(94)90098-1. [PubMed:7954976 ]
Tojo K, Oota M, Honda H, Shibasaki T, Sakai O: Possible thyroidal involvement in a case of Fabry disease. Intern Med. 1994 Mar;33(3):172-6. doi: 10.2169/internalmedicine.33.172. [PubMed:8061397 ]
Holleran WM, Ginns EI, Menon GK, Grundmann JU, Fartasch M, McKinney CE, Elias PM, Sidransky E: Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest. 1994 Apr;93(4):1756-64. doi: 10.1172/JCI117160. [PubMed:8163674 ]
Schafer A, Harzer K, Kattner E, Schafer HJ, Stoltenburg G, Lietz H: [Disseminated lipogranulomatosis (Farber disease) with hydrops fetalis]. Pathologe. 1996 Mar;17(2):145-9. doi: 10.1007/s002920050148. [PubMed:8650144 ]
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Futerman AH: The roles of ceramide in the regulation of neuronal growth and development. Biochemistry (Mosc). 1998 Jan;63(1):74-83. [PubMed:9526098 ]
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Gill JS, Windebank AJ: Suramin induced ceramide accumulation leads to apoptotic cell death in dorsal root ganglion neurons. Cell Death Differ. 1998 Oct;5(10):876-83. doi: 10.1038/sj.cdd.4400410. [PubMed:10203686 ]
Herr I, Martin-Villalba A, Kurz E, Roncaioli P, Schenkel J, Cifone MG, Debatin KM: FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. Brain Res. 1999 May 1;826(2):210-9. doi: 10.1016/s0006-8993(99)01288-3. [PubMed:10224298 ]
Di Marzio L, Cinque B, De Simone C, Cifone MG: Effect of the lactic acid bacterium Streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo. J Invest Dermatol. 1999 Jul;113(1):98-106. doi: 10.1046/j.1523-1747.1999.00633.x. [PubMed:10417626 ]
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Bektas M, Orfanos CE, Geilen CC: Different vitamin D analogues induce sphingomyelin hydrolysis and apoptosis in the human keratinocyte cell line HaCaT. Cell Mol Biol (Noisy-le-grand). 2000 Feb;46(1):111-9. [PubMed:10726977 ]
Garcia-Ruiz C, Mari M, Morales A, Colell A, Ardite E, Fernandez-Checa JC: Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes. Hepatology. 2000 Jul;32(1):56-65. doi: 10.1053/jhep.2000.8267. [PubMed:10869289 ]
Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S: Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000 Sep;143(3):524-31. doi: 10.1111/j.1365-2133.2000.03705.x. [PubMed:10971324 ]
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Lew BL, Cho Y, Kim J, Sim WY, Kim NI: Ceramides and cell signaling molecules in psoriatic epidermis: reduced levels of ceramides, PKC-alpha, and JNK. J Korean Med Sci. 2006 Feb;21(1):95-9. doi: 10.3346/jkms.2006.21.1.95. [PubMed:16479073 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for Cer(d18:1/16:0) (MMDBc0000607)

MOL for #<Metabolite:0x00007f09200bfad8>

3D MOL for #<Metabolite:0x00007f09200bfad8>

3D SDF for #<Metabolite:0x00007f09200bfad8>

3D-SDF for #<Metabolite:0x00007f09200bfad8>

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3D PDB for #<Metabolite:0x00007f09200bfad8>

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INCHI for #<Metabolite:0x00007f09200bfad8>

Structure for #<Metabolite:0x00007f09200bfad8>

3D Structure for #<Metabolite:0x00007f09200bfad8>