Record Information Version 1.0 Status Detected and Quantified Creation Date 2020-12-10 18:52:54 UTC Update Date 2022-08-31 06:11:06 UTC MiMeDB ID MMDBc0000694 Metabolite Identification Common Name Thioproline Description Thioproline (CAS: 444-27-9), also known as 1,3-thiazolidine-4-carboxylic acid or gamma-thioproline, belongs to the class of organic compounds known as L-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Thioproline has been identified in the human placenta (PMID: 32033212 ). Structure Synonyms Not Available Chemical Formula C4 H7 NO2 S Average Molecular Weight 133.169 Monoisotopic Molecular Weight 133.019749163 IUPAC Name Not Available Traditional Name Not Available CAS Registry Number Not Available SMILES Not Available InChI Identifier InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1
InChI Key DZLNHFMRPBPULJ-VKHMYHEASA-N Chemical Taxonomy Functional Ontology Not Available Physical Properties State Expected Solid Predicted Properties Not Available Spectra Not Available Biological Properties Cellular Locations Not Available Biospecimen Locations Blood
Feces
Placenta
Urine Tissue Locations Associated OMIM IDs 114500 (Colorectal cancer)610247 (Eosinophilic esophagitis)Human Proteins and Enzymes Proteins Human Pathways Pathways Metabolic Reactions Not Available
Health Effects and Bioactivity Health Outcome/Bioactivity Metabolite Response/Effect Related Health Condition Evidence Type Measured in Matrix Data Source Reference
Microbial Sources Kingdom Phylum Total species Hosts and Body Sites Microbial Links Firmicutes 3 Indirect association between microbiota composition and metabolites measured in host biospecimen
Exposure Sources Source Type Source Sub-type Species Data Source Reference Details
Host Biospecimen and Location Host and Biospecimen Status Mean Std Min Max Units Age Sex Health Condition Data Source Reference Human Detected and Quantified 0.26 0.46 Adult (>18 years old) Male Normal HMDB 27012787 detailsHuman Detected and Quantified 0.28 0.69 Adult (>18 years old) Female Normal HMDB 27012787 detailsHuman Placenta Detected but not Quantified Not Specified Not Specified Normal HMDB 34986597 detailsHuman Feces Detected but not Quantified Adult (>18 years old) Both Normal HMDB 29808030 detailsHuman Detected but not Quantified HMDB details
External Links External Links Not Available References Synthesis Reference Not Available General References Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]
