MiMeDB: Showing metabocard for N6-Carboxymethyllysine (MMDBc0000750)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-12-10 18:54:10 UTC

Update Date

2022-08-31 06:11:54 UTC

MiMeDB ID

MMDBc0000750

Metabolite Identification

Common Name

N6-Carboxymethyllysine

Description

N6-Carboxymethyllysine (CML), also known as epsilon-(carboxymethyl)lysine, belongs to the class of organic compounds known as L-alpha-amino acids. These are alpha-amino acids which have the L-configuration of the alpha-carbon atom. CML is a Maillard reaction product, or dietary advanced glycation end-products (d-AGE), formed as a result of the thermal treatment of foods. Due to its chemical stability and its ubiquity in foods and in vivo, CML is used as a biomarker for the ingestion of thermally treated foods. CML is metabolized by intestinal bacteria under anaerobic conditions (PMID: 31091091 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₈H₁₆N₂O₄

Average Molecular Weight

204.226

Monoisotopic Molecular Weight

204.111007003

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C8H16N2O4/c9-6(8(13)14)3-1-2-4-10-5-7(11)12/h6,10H,1-5,9H2,(H,11,12)(H,13,14)/t6-/m0/s1

InChI Key

NUXSIDPKKIEIMI-LURJTMIESA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Blood
Feces
Placenta
Urine

Tissue Locations

Placenta

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Not Available

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Phylum	Total species	Hosts and Body Sites	Microbial Links
Verrucomicrobia	1	Human Feces	Indirect association between microbiota composition and metabolites measured in host biospecimen
Bacteroidetes	1	Human Feces	Indirect association between microbiota composition and metabolites measured in host biospecimen
Firmicutes	4		Indirect association between microbiota composition and metabolites measured in host biospecimen

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Age	Sex	Health Condition	Data Source	Reference
Human Placenta	Detected but not Quantified	Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Feces	Detected but not Quantified	Adult (>18 years old)	Both	Normal	HMDB	29808030	details
Human Urine	Detected but not Quantified	Adult (>18 years old)	Both	Normal	HMDB	32966057	details
Human Blood	Detected but not Quantified	Adult (>18 years old)	Both	Normal	HMDB	32966057	details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Bui TPN, Troise AD, Fogliano V, de Vos WM: Anaerobic Degradation of N-epsilon-Carboxymethyllysine, a Major Glycation End-Product, by Human Intestinal Bacteria. J Agric Food Chem. 2019 Jun 12;67(23):6594-6602. doi: 10.1021/acs.jafc.9b02208. Epub 2019 May 28. [PubMed:31091091 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for N6-Carboxymethyllysine (MMDBc0000750)

MOL for #<Metabolite:0x000055b76db4e680>

3D MOL for #<Metabolite:0x000055b76db4e680>

3D SDF for #<Metabolite:0x000055b76db4e680>

3D-SDF for #<Metabolite:0x000055b76db4e680>

PDB for #<Metabolite:0x000055b76db4e680>

3D PDB for #<Metabolite:0x000055b76db4e680>

SMILES for #<Metabolite:0x000055b76db4e680>

INCHI for #<Metabolite:0x000055b76db4e680>

Structure for #<Metabolite:0x000055b76db4e680>

3D Structure for #<Metabolite:0x000055b76db4e680>