MiMeDB: Showing metabocard for Cortisone (MMDBc0000769)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-12-10 18:54:32 UTC

Update Date

2022-08-31 06:12:17 UTC

MiMeDB ID

MMDBc0000769

Metabolite Identification

Common Name

Cortisone

Description

Cortisone is a naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver into the active metabolite cortisol. Cortisone is a corticosteroid hormone released by the adrenal gland in response to stress. One of cortisone's effects on the body, and a potentially harmful side effect when administered clinically, is the suppression of the immune system. This is an explanation for the apparent correlation between high stress and sickness.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₁H₂₈O₅

Average Molecular Weight

360.444

Monoisotopic Molecular Weight

360.193674006

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChI Key

MFYSYFVPBJMHGN-ZPOLXVRWSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Endoplasmic reticulum
Extracellular
Membrane

Biospecimen Locations

Adipose Tissue
Adrenal Cortex
Adrenal Gland
Blood
Epidermis
Feces
Fibroblasts
Intestine
Kidney
Neuron
Placenta
Skeletal Muscle
Testis
Thyroid Gland
Urine

Tissue Locations

Adipose Tissue
Adrenal Cortex
Adrenal Gland
Epidermis
Fibroblasts
Intestine
Kidney
Neuron
Placenta
Skeletal Muscle
Testis
Thyroid Gland

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76dcc4e10>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference
Depersonalization disorder	Slight Decrease	This associated disease is originally imported from HMDB metabolite HMDB0002802 concentration id 17393	Association	Human Blood		11448093	details
Rheumatoid arthritis	Decreased	This associated disease is originally imported from HMDB metabolite HMDB0002802 concentration id 58611	Association	Human Urine		15249323	details

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Firmicutes	1	Human	Indirect association between microbiota composition and metabolites measured in host biospecimen

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified								HMDB		details
Human	Detected and Quantified	0.0466	0.0071			Adult (>18 years old)	Both	Depersonalization syndrome	HMDB	11448093	details
Human	Detected and Quantified	0.0039	0.0012			Adult (>18 years old)	Both	Rheumatoid arthritis	HMDB	15249323	details
Human	Detected and Quantified	0.0070	0.0014			Adult (>18 years old)	Both	Rheumatoid arthritis	HMDB	15249323	details
Human	Detected and Quantified	0.011	0.001			Adult (>18 years old)	Both	Normal	HMDB	15249323	details
Human	Detected and Quantified	0.0380		0.0222	0.0750	Adult (>18 years old)	Female	Normal	HMDB	15087250	details
Human	Detected and Quantified	0.0411		0.0222	0.0750	Adult (>18 years old)	Male	Normal	HMDB	15087250	details
Human	Detected and Quantified	0.0624	0.009			Adult (>18 years old)	Both	Normal	HMDB	11448093	details
Human Adipose Tissue	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Adrenal Cortex	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Adrenal Gland	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Epidermis	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Fibroblasts	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Intestine	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Kidney	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Neuron	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Placenta	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Skeletal Muscle	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Testis	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Thyroid Gland	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Urine	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	32966057	details
Human Blood	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	32966057	details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Pepe GJ, Albrecht ED: Regulation of the primate fetal adrenal cortex. Endocr Rev. 1990 Feb;11(1):151-76. doi: 10.1210/edrv-11-1-151. [PubMed:2180686 ]
Zuber M, Miesel R, Brandl B: A patient with a high titer of antinuclear antibody and a functioning adrenal tumour. Clin Rheumatol. 1995 Jan;14(1):100-3. doi: 10.1007/BF02208093. [PubMed:7743733 ]
Stormer FC, Reistad R, Alexander J: Glycyrrhizic acid in liquorice--evaluation of health hazard. Food Chem Toxicol. 1993 Apr;31(4):303-12. doi: 10.1016/0278-6915(93)90080-i. [PubMed:8386690 ]
Weigand A, Hinzpeter B, Schicha H: [Deterioration of endocrine ophthalmology after radioiodine therapy in Graves' disease?]. Nuklearmedizin. 1998;37(7):234-8. [PubMed:9830613 ]
Boman HG: Innate immunity and the normal microflora. Immunol Rev. 2000 Feb;173:5-16. doi: 10.1034/j.1600-065x.2000.917301.x. [PubMed:10719663 ]
Edwin B, Raeder I, Trondsen E, Kaaresen R, Buanes T: Outpatient laparoscopic adrenalectomy in patients with Conn's syndrome. Surg Endosc. 2001 Jun;15(6):589-91. doi: 10.1007/s004640090021. Epub 2001 Mar 13. [PubMed:11591947 ]
Ferrari P, Bianchetti M, Frey FJ: Juvenile hypertension, the role of genetically altered steroid metabolism. Horm Res. 2001;55(5):213-23. doi: 10.1159/000049999. [PubMed:11740142 ]
Bolt RJ, Van Weissenbruch MM, Popp-Snijders C, Sweep FG, Lafeber HN, Delemarre-van de Waal HA: Maturity of the adrenal cortex in very preterm infants is related to gestational age. Pediatr Res. 2002 Sep;52(3):405-10. doi: 10.1203/00006450-200209000-00017. [PubMed:12193676 ]
Jiang JQ, Wang DS, Senthilkumaran B, Kobayashi T, Kobayashi HK, Yamaguchi A, Ge W, Young G, Nagahama Y: Isolation, characterization and expression of 11beta-hydroxysteroid dehydrogenase type 2 cDNAs from the testes of Japanese eel (Anguilla japonica) and Nile tilapia (Oreochromis niloticus). J Mol Endocrinol. 2003 Oct;31(2):305-15. doi: 10.1677/jme.0.0310305. [PubMed:14519098 ]
AvRuskin TW, Krishnan N, Juan CS: Congenital adrenal hypoplasia and male pseudohermaphroditism due to DAX1 mutation, SF1 mutation or neither: a patient report. J Pediatr Endocrinol Metab. 2004 Aug;17(8):1125-32. doi: 10.1515/jpem.2004.17.8.1125. [PubMed:15379426 ]
Sandeep TC, Andrew R, Homer NZ, Andrews RC, Smith K, Walker BR: Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes. 2005 Mar;54(3):872-9. doi: 10.2337/diabetes.54.3.872. [PubMed:15734867 ]
Andrew R, Westerbacka J, Wahren J, Yki-Jarvinen H, Walker BR: The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes. 2005 May;54(5):1364-70. doi: 10.2337/diabetes.54.5.1364. [PubMed:15855321 ]
Draper N, Stewart PM: 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action. J Endocrinol. 2005 Aug;186(2):251-71. doi: 10.1677/joe.1.06019. [PubMed:16079253 ]
Sharma KK, Lindqvist A, Zhou XJ, Auchus RJ, Penning TM, Andersson S: Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):79-86. doi: 10.1016/j.mce.2005.10.024. Epub 2005 Dec 5. [PubMed:16337083 ]
Mark PJ, Waddell BJ: P-glycoprotein restricts access of cortisol and dexamethasone to the glucocorticoid receptor in placental BeWo cells. Endocrinology. 2006 Nov;147(11):5147-52. doi: 10.1210/en.2006-0633. Epub 2006 Jul 27. [PubMed:16873536 ]
Onyimba CU, Vijapurapu N, Curnow SJ, Khosla P, Stewart PM, Murray PI, Walker EA, Rauz S: Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye. J Endocrinol. 2006 Aug;190(2):483-93. doi: 10.1677/joe.1.06840. [PubMed:16899581 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for Cortisone (MMDBc0000769)

MOL for #<Metabolite:0x000055b769f30a18>

3D MOL for #<Metabolite:0x000055b769f30a18>

3D SDF for #<Metabolite:0x000055b769f30a18>

3D-SDF for #<Metabolite:0x000055b769f30a18>

PDB for #<Metabolite:0x000055b769f30a18>

3D PDB for #<Metabolite:0x000055b769f30a18>

SMILES for #<Metabolite:0x000055b769f30a18>

INCHI for #<Metabolite:0x000055b769f30a18>

Structure for #<Metabolite:0x000055b769f30a18>

3D Structure for #<Metabolite:0x000055b769f30a18>