Showing metabocard for 2-mMethyl-phenol (MMDBc0001073)
Record Information
Version
1.0
Status
Detected and Quantified
Creation Date
2021-05-14 18:42:39 UTC
Update Date
2022-08-31 06:17:34 UTC
MiMeDB ID
MMDBc0001073
Metabolite Identification
Common Name
2-mMethyl-phenol
Description
2-Methyl-phenol, also known as o-Cresol, is a minor urinary metabolite of toluene. 2-methyl-phenol is a cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene. It has a role as a human xenobiotic metabolite. It is widely used chemical with neurotoxicological properties (PMID:15687000 ). 2-Methyl-phenol is used commercially as a disinfectant. Exposure may occur by inhalation, by cutaneous adsorption or by oral ingestion. 2-Methyl-phenol denature and precipitate cellular proteins and thus may rapidly cause poisoning. 2-Methyl-phenol is metabolized by conjugation and oxidation. Ingestion of 2-methyl-phenol cause intense burning of mouth and throat, followed by marked abdominal pain and distress. The minimum lethal dose of cresol by mouth is about 2 g (PMID 15040915 ). 2-Methyl-phenol is a microbial metabolite that can be found in Pseudomonas. Besides, 2-methyl-phenol is one of the chemical compounds found in castoreum. This compound is gathered from the beaver's castor glands and found in the white cedar consumed by the beavers. Together with many other compounds, 2-methyl-phenol is traditionally extracted from coal tar, the volatile materials obtained in the production of coke from coal. A similar source material is petroleum residues. These residue contains a few percent by weight of phenol and isomeric cresols. In addition to the materials derived from these natural sources, about two thirds of the Western world's supply is produced by methylation of phenol using methanol.
Boatto G, Nieddu M, Carta A, Pau A, Lorenzoni S, Manconi P, Serra D: Determination of phenol and o-cresol by GC/MS in a fatal poisoning case. Forensic Sci Int. 2004 Jan 28;139(2-3):191-4. doi: 10.1016/j.forsciint.2003.10.023. [PubMed:15040915 ]
Fustinoni S, Mercadante R, Campo L, Scibetta L, Valla C, Foa V: Determination of urinary ortho- and meta-cresol in humans by headspace SPME gas chromatography/mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Mar 25;817(2):309-17. doi: 10.1016/j.jchromb.2004.12.029. [PubMed:15687000 ]
