MiMeDB: Showing metabocard for Glucosamine 6-phosphate (MMDBc0029600)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:33:55 UTC

Update Date

2022-08-31 13:58:51 UTC

MiMeDB ID

MMDBc0029600

Metabolite Identification

Common Name

Glucosamine 6-phosphate

Description

Glucosamine 6-phosphate is normally produced via the de novo glucosamine synthesis by the enzyme fructose-6-phosphate amidotransferase and the modulation of this pathway by glutamine. Glutamine-fructose-6-phosphate amidotransferase (GFAT) catalyzes the first committed step in the pathway for biosynthesis of hexosamines. A member of the N-terminal nucleophile class of amidotransferases, GFAT transfers the amino group from the L-glutamine amide to D-fructose 6-phosphate, producing glutamic acid and glucosamine 6-phosphate. (PMID 11270676 , 11842094 )

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₆H₁₄NO₈P

Average Molecular Weight

259.151

Monoisotopic Molecular Weight

259.045702941

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

3616-42-0

SMILES

Not Available

InChI Identifier

InChI=1S/C6H14NO8P/c7-3-5(9)4(8)2(15-6(3)10)1-14-16(11,12)13/h2-6,8-10H,1,7H2,(H2,11,12,13)/t2-,3-,4-,5-,6+/m1/s1

InChI Key

XHMJOUIAFHJHBW-UKFBFLRUSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Lysosome

Biospecimen Locations

Feces
Placenta

Tissue Locations

Placenta

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x0000564abf9b45c8>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Proteobacteria	270	Human Feces; Human ; Pig ; Chicken	Unknown; Metabolic reconstruction;
	Firmicutes	481	Human Feces; Pig ; Human ; Cattle ; Catfish	Metabolic reconstruction;
	Actinobacteria	141	Human Feces; Human	Metabolic reconstruction;
	Verrucomicrobia	1	Human	Metabolic reconstruction
	Bacteroidetes	127	Human Feces; Human	Metabolic reconstruction;
	Synergistetes	4	Human Feces	Metabolic reconstruction
	Spirochaetes	7	Human Feces; Human	Metabolic reconstruction;
	Thaumarchaeota	1	Human Feces	Metabolic reconstruction
	Fusobacteria	20	Human Feces; Human	Metabolic reconstruction
	Euryarchaeota	5	Human Feces; Cattle ; Human	Metabolic reconstruction
	Candidatus Melainabacteria	1	Human Feces	Metabolic reconstruction
	Tenericutes	7	Human Feces; Human	Metabolic reconstruction;
	Planctomycetes	2	Human Feces	Metabolic reconstruction;
	Crenarchaeota	1	Human Feces	Metabolic reconstruction
Archaea	Euryarchaeota	1
Fungi	Ascomycota	2	Human Feces	; Unknown
NULL	Proteobacteria	1

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details
Animal	Milk	Bos taurus	FooDB	31437929	details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB		details
Human Placenta	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597	details

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Wu G, Haynes TE, Yan W, Meininger CJ: Presence of glutamine:fructose-6-phosphate amidotransferase for glucosamine-6-phosphate synthesis in endothelial cells: effects of hyperglycaemia and glutamine. Diabetologia. 2001 Feb;44(2):196-202. doi: 10.1007/s001250051599. [PubMed:11270676 ]
Broschat KO, Gorka C, Page JD, Martin-Berger CL, Davies MS, Huang Hc HC, Gulve EA, Salsgiver WJ, Kasten TP: Kinetic characterization of human glutamine-fructose-6-phosphate amidotransferase I: potent feedback inhibition by glucosamine 6-phosphate. J Biol Chem. 2002 Apr 26;277(17):14764-70. doi: 10.1074/jbc.M201056200. Epub 2002 Feb 12. [PubMed:11842094 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for Glucosamine 6-phosphate (MMDBc0029600)

MOL for #<Metabolite:0x0000564abf85b550>

3D MOL for #<Metabolite:0x0000564abf85b550>

3D SDF for #<Metabolite:0x0000564abf85b550>

3D-SDF for #<Metabolite:0x0000564abf85b550>

PDB for #<Metabolite:0x0000564abf85b550>

3D PDB for #<Metabolite:0x0000564abf85b550>

SMILES for #<Metabolite:0x0000564abf85b550>

INCHI for #<Metabolite:0x0000564abf85b550>

Structure for #<Metabolite:0x0000564abf85b550>

3D Structure for #<Metabolite:0x0000564abf85b550>