MiMeDB: Showing metabocard for ADP (MMDBc0029623)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:35:02 UTC

Update Date

2022-08-31 14:14:28 UTC

MiMeDB ID

MMDBc0029623

Metabolite Identification

Common Name

ADP

Description

Adenosine diphosphate, abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleotide adenine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₁₀H₁₅N₅O₁₀P₂

Average Molecular Weight

427.2011

Monoisotopic Molecular Weight

427.029414749

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

58-64-0

SMILES

Not Available

InChI Identifier

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI Key

XTWYTFMLZFPYCI-KQYNXXCUSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Endoplasmic reticulum
Extracellular
Mitochondria
Nucleus
Peroxisome

Biospecimen Locations

All Tissues
Blood
Cellular Cytoplasm
Cerebrospinal Fluid (CSF)
Feces
Saliva
Urine

Tissue Locations

All Tissues

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x0000564abfb672f8>

Human Pathways

Pathways

Name	SMPDB/PathBank
Lafutidine H2-Antihistamine Action
Ubiquitin–Proteasome Pathway
Mevalonate Pathway
1-Methylhistidine Metabolism

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Reference
Epilepsy	Decreased	This associated disease is originally imported from HMDB metabolite HMDB0001341 concentration id 16283	Association	Human Cerebrospinal Fluid (CSF)	15993662	details
Neuroinfection		This associated disease is originally imported from HMDB metabolite HMDB0001341 concentration id 16285	Association	Human Cerebrospinal Fluid (CSF)	15993662	details
Rachialgia	Decreased	This associated disease is originally imported from HMDB metabolite HMDB0001341 concentration id 16281	Association	Human Cerebrospinal Fluid (CSF)	15993662	details
Stroke		This associated disease is originally imported from HMDB metabolite HMDB0001341 concentration id 16284	Association	Human Cerebrospinal Fluid (CSF)	15993662	details
Subarachnoid hemorrhage	Decreased	This associated disease is originally imported from HMDB metabolite HMDB0001341 concentration id 16282	Association	Human Cerebrospinal Fluid (CSF)	15993662	details
Eosinophilic esophagitis	Slight Increase	This associated disease is originally imported from HMDB metabolite HMDB0001341 concentration id 98162	Association	Human Urine	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)	details

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Proteobacteria	689	Human Feces; Human ; Pig ; Turkey ; Cattle ; Chicken ; Rat ; Sheep ; Lion ; American dog tick ; Dog ; Cat	Unknown; Metabolic reconstruction;
	Firmicutes	575	Human Feces; Pig ; Human ; Cattle ; Catfish	Metabolic reconstruction;
	Actinobacteria	218	Human Feces; Human ; Cattle	Metabolic reconstruction;
	Verrucomicrobia	3	Human	Metabolic reconstruction;
	Bacteroidetes	139	Human Feces; Human	Metabolic reconstruction;
	Synergistetes	5	Human Feces	Metabolic reconstruction;
	Spirochaetes	20	Human Feces; Human ; Pig	Metabolic reconstruction;
	Thaumarchaeota	1	Human Feces	Metabolic reconstruction
	Fusobacteria	22	Human Feces; Human	Metabolic reconstruction;
	Euryarchaeota	8	Human Feces; Cattle ; Human	Metabolic reconstruction;
	Candidatus Melainabacteria	1	Human Feces	Metabolic reconstruction
	Tenericutes	29	Human Feces; Human ; Goat ; Pig	Metabolic reconstruction;
	Planctomycetes	2	Human Feces	Metabolic reconstruction;
	Crenarchaeota	1	Human Feces	Metabolic reconstruction
Archaea	Euryarchaeota	46
		12
	Cyanobacteria	35	Human
Fungi	Ascomycota	110	Human Feces	; Unknown
	Deinococcus-Thermus	10
NULL	Proteobacteria	11
	Chloroflexi	11
	Aquificae	5
	Chlorobi	13	Human
	Thermotogae	12
	Acidobacteria	3
	Nitrospirae	1
	Chlamydiae	12	Human ; Cat
NULL	Tenericutes	2
Fungi	Basidiomycota	20	Human Feces
	Dictyoglomi	2
	Elusimicrobia	2
	Gemmatimonadetes	1
Archaea		12
Archaea	Crenarchaeota	23
Fungi	Microsporidia	4
Orthornavirae	Kitrinoviricota	197
Orthornavirae	Duplornaviricota	6
Heunggongvirae	Uroviricota	6
Bamfordvirae	Nucleocytoviricota	36
	Uroviricota	11
Shotokuvirae	Cressdnaviricota	12
Shotokuvirae	Cossaviricota	106
Orthornavirae	Pisuviricota	60
Virus		1
NULL	Firmicutes	2
NULL	Actinobacteria	4
Fungi	Mucoromycota	2
Archaea	Thaumarchaeota	2
	Fibrobacteres	1
Fungi	Chytridiomycota	2
	Peploviricota	20
Heunggongvirae	Peploviricota	16
NULL		1
Archaea	Korarchaeota	1
NULL	Aquificae	1
Archaea	Nanoarchaeota	1

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified								HMDB		details
Human	Detected and Quantified	0.63	0.37			Adult (>18 years old)	Both	Epilepsy	HMDB	15993662	details
Human	Detected and Quantified	1.62	0.96			Adult (>18 years old)	Both	Neuroinfection	HMDB	15993662	details
Human	Detected and Quantified	1.10	0.60			Adult (>18 years old)	Both	Rachialgia	HMDB	15993662	details
Human	Detected and Quantified	1.86	1.67			Adult (>18 years old)	Both	Stroke	HMDB	15993662	details
Human	Detected and Quantified	0.91	0.46			Adult (>18 years old)	Both	Subarachnoid hemorrhage	HMDB	15993662	details
Human	Detected and Quantified	1.23	0.13			Adult (>18 years old)	Both	Normal	HMDB	11310987	details
Human	Detected and Quantified	1.26	0.19			Adult (>18 years old)	Both	Normal	HMDB	11310987	details
Human	Detected and Quantified	1.39	0.16			Adult (>18 years old)	Both	Normal	HMDB	11310987	details
Human	Detected and Quantified	1.8		1.0	3.4	Adult (>18 years old)	Both	Normal	HMDB	24023812	details
Human	Detected and Quantified	1.90	0.025			Adult (>18 years old)	Both	Normal	HMDB	15993662	details
Human	Detected and Quantified	270		150	390	Adult (>18 years old)	Both	Normal	HMDB	15882454	details
Human	Detected and Quantified	3.242	1.657			Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)	details
Human	Detected and Quantified	2.654	2.236			Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)	details
Human	Detected and Quantified	160.0	14.0			Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human	Detected and Quantified	0.0257	0.0618			Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.	details
Human	Detected and Quantified	0.169	0.234			Adult (>18 years old)	Not Specified	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.	details
Human	Detected and Quantified	0.207	0.324			Adult (>18 years old)	Both	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.	details
Human	Detected and Quantified	0.298	0.316			Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.	details
Human	Detected and Quantified	0.317	0.491			Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.	details
Human	Detected and Quantified	0.387	0.462			Adult (>18 years old)	Not Specified	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.	details
Human	Detected and Quantified	0.433	0.363			Adult (>18 years old)	Both	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.	details
Human All Tissues	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Vigue C, Vigue L, Huszar G: Adenosine triphosphate (ATP) concentrations and ATP/adenosine diphosphate ratios in human sperm of normospermic, oligospermic, and asthenospermic specimens and in their swim-up fractions: lack of correlation between ATP parameters and sperm creatine kinase concentrations. J Androl. 1992 Jul-Aug;13(4):305-11. [PubMed:1399831 ]
Imura Y, Stassen JM, Bunting S, Stockmans F, Collen D: Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg-Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model. Blood. 1992 Sep 1;80(5):1247-53. [PubMed:1515641 ]
Morshedi M, Oehninger S, Blackmore P, Bocca S, Coddington C, Hodgen G: Investigation of some biochemical and functional effects of cryopreservation of human spermatozoa using an automated freezing-quick-thawing method. Int J Androl. 1995 Dec;18(6):279-86. doi: 10.1111/j.1365-2605.1995.tb00563.x. [PubMed:8719843 ]
Hua J, Suguro S, Iwabuchi K, Tsutsumi-Ishii Y, Sakamoto K, Nagaoka I: Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-mediated platelet activation in humans. Inflamm Res. 2004 Dec;53(12):680-8. doi: 10.1007/s00011-004-1312-y. [PubMed:15654516 ]
Smith SM, Judge HM, Peters G, Storey RF: Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention. Platelets. 2004 Dec;15(8):465-74. doi: 10.1080/0953710412331272532. [PubMed:15763887 ]
Quinton TM, Kim S, Jin J, Kunapuli SP: Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 2005 May;3(5):1036-41. doi: 10.1111/j.1538-7836.2005.01325.x. [PubMed:15869601 ]
Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18. doi: 10.1186/1742-4682-2-18. [PubMed:15882454 ]
Ji Q, Ghaly M, Hjemdahl P, Tornvall P, Li N: Contrast medium attenuates platelet activation and platelet-leukocyte cross-talk. Thromb Haemost. 2005 May;93(5):922-6. doi: 10.1160/TH04-12-0809. [PubMed:15886810 ]
Corsonello A, Malara A, De Domenico D, Damiano MC, Mirone S, Loddo S, Ientile R, Corica F: Effects of magnesium sulphate on leptin-dependent platelet aggregation: an ex vivo study. Magnes Res. 2005 Mar;18(1):7-11. [PubMed:15945611 ]
Shabanova EY, Mindukshev IV, Malakhovskaya EA, Vivulanets EV, Petrishchev NN, Krivchenko AI: Cooperative type of platelet hypersensitivity to ADP. Bull Exp Biol Med. 2005 Sep;140(3):282-4. doi: 10.1007/s10517-005-0467-z. [PubMed:16307036 ]
Cuisset T, Frere C, Quilici J, Barbou F, Morange PE, Hovasse T, Bonnet JL, Alessi MC: High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost. 2006 Mar;4(3):542-9. doi: 10.1111/j.1538-7836.2005.01751.x. Epub 2005 Dec 22. [PubMed:16371119 ]
Saxena R, Gupta M, Gupta S, Kannan M, Ahmed RP, Choudhry VP: Inherited heterogenous defect in platelet aggregation selectively with ADP and epinephrine--a series of 25 cases. Indian J Pathol Microbiol. 2005 Jul;48(3):345-8. [PubMed:16761747 ]
Cuisset T, Frere C, Quilici J, Morange PE, Nait-Saidi L, Carvajal J, Lehmann A, Lambert M, Bonnet JL, Alessi MC: Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol. 2006 Oct 3;48(7):1339-45. doi: 10.1016/j.jacc.2006.06.049. Epub 2006 Sep 12. [PubMed:17010792 ]

Showing metabocard for ADP (MMDBc0029623)

MOL for #<Metabolite:0x0000564abd71b278>

3D MOL for #<Metabolite:0x0000564abd71b278>

3D SDF for #<Metabolite:0x0000564abd71b278>

3D-SDF for #<Metabolite:0x0000564abd71b278>

PDB for #<Metabolite:0x0000564abd71b278>

3D PDB for #<Metabolite:0x0000564abd71b278>

SMILES for #<Metabolite:0x0000564abd71b278>

INCHI for #<Metabolite:0x0000564abd71b278>

Structure for #<Metabolite:0x0000564abd71b278>

3D Structure for #<Metabolite:0x0000564abd71b278>