MiMeDB: Showing metabocard for Glycineamideribotide (MMDBc0029672)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:36:56 UTC

Update Date

2022-08-31 17:11:37 UTC

MiMeDB ID

MMDBc0029672

Metabolite Identification

Common Name

Glycineamideribotide

Description

Glycinamidoribotide conversion to N-formylglycinamide ribonucleotide is the third reaction of the de novo purine biosynthesis, a reaction catalyzed by the enzyme glycinamide ribonucleotide transformylase (EC 2.1.2.2). Glycinamide ribonucleotide (GAR) synthetase catalyzes the conversion of phosphoribosylamine, glycine, and MgATP to glycinamide ribonucleotide. (PMID: 2182115 )

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₇H₁₅N₂O₈P

Average Molecular Weight

286.1764

Monoisotopic Molecular Weight

286.056601978

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

10074-18-7

SMILES

Not Available

InChI Identifier

InChI=1S/C7H15N2O8P/c8-1-4(10)9-7-6(12)5(11)3(17-7)2-16-18(13,14)15/h3,5-7,11-12H,1-2,8H2,(H,9,10)(H2,13,14,15)/t3-,5-,6-,7-/m1/s1

InChI Key

OBQMLSFOUZUIOB-SHUUEZRQSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Feces

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76be1d098>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Proteobacteria	182	Human Feces; Human ; Pig	Unknown; Metabolic reconstruction
	Firmicutes	383	Human Feces; Pig ; Human ; Cattle	Metabolic reconstruction
	Actinobacteria	126	Human Feces; Human	Metabolic reconstruction
	Verrucomicrobia	1	Human	Metabolic reconstruction
	Bacteroidetes	126	Human Feces; Human	Metabolic reconstruction
	Synergistetes	4	Human Feces	Metabolic reconstruction
	Spirochaetes	1	Human Feces	Metabolic reconstruction
	Thaumarchaeota	1	Human Feces	Metabolic reconstruction
	Fusobacteria	20	Human Feces; Human	Metabolic reconstruction
	Euryarchaeota	5	Human Feces; Cattle ; Human	Metabolic reconstruction
	Candidatus Melainabacteria	1	Human Feces	Metabolic reconstruction
	Planctomycetes	1	Human Feces	Metabolic reconstruction
	Crenarchaeota	1	Human Feces	Metabolic reconstruction
Fungi	Ascomycota	1	Human Feces	Unknown

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB		details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

McKerns KW: Gonadotropin regulation of nucleotide biosynthesis in corpus luteum. Biochemistry. 1973 Dec 4;12(25):5206-11. doi: 10.1021/bi00749a030. [PubMed:4366083 ]
Caperelli CA, Giroux EL: The human glycinamide ribonucleotide transformylase domain: purification, characterization, and kinetic mechanism. Arch Biochem Biophys. 1997 May 1;341(1):98-103. doi: 10.1006/abbi.1997.9947. [PubMed:9143358 ]

Showing metabocard for Glycineamideribotide (MMDBc0029672)

MOL for #<Metabolite:0x000055b76c5b0ff8>

3D MOL for #<Metabolite:0x000055b76c5b0ff8>

3D SDF for #<Metabolite:0x000055b76c5b0ff8>

3D-SDF for #<Metabolite:0x000055b76c5b0ff8>

PDB for #<Metabolite:0x000055b76c5b0ff8>

3D PDB for #<Metabolite:0x000055b76c5b0ff8>

SMILES for #<Metabolite:0x000055b76c5b0ff8>

INCHI for #<Metabolite:0x000055b76c5b0ff8>

Structure for #<Metabolite:0x000055b76c5b0ff8>

3D Structure for #<Metabolite:0x000055b76c5b0ff8>