Record Information Version 1.0 Status Detected and Quantified Creation Date 2021-11-17 23:42:10 UTC Update Date 2022-08-31 17:18:19 UTC MiMeDB ID MMDBc0029800 Metabolite Identification Common Name 2-Phospho-D-glyceric acid Description 2-Phospho-D-glycerate or 2PG is an intermediate in gluconeogenesis. It is a glyceric acid which serves as the substrate in the ninth step of glycolysis. 2PG is converted by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate. More specifically, 2PG can be generated from Glycerate-3-phosphate via phosphoglycerate mutase or from phosphoenolpyrvate via alpha enolase. Structure Synonyms Not Available Chemical Formula C3 H7 O7 P Average Molecular Weight 186.0572 Monoisotopic Molecular Weight 185.99293909 IUPAC Name Not Available Traditional Name Not Available CAS Registry Number Not Available SMILES Not Available InChI Identifier InChI=1S/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1
InChI Key GXIURPTVHJPJLF-UWTATZPHSA-N Chemical Taxonomy Functional Ontology Not Available Physical Properties State Solid Predicted Properties Not Available Spectra Not Available Biological Properties Cellular Locations Biospecimen Locations Tissue Locations Associated OMIM IDs 114500 (Colorectal cancer)610247 (Eosinophilic esophagitis)Human Proteins and Enzymes Proteins #<MetaboliteProteinLink:0x0000564abda3fa80> Human Pathways Pathways Metabolic Reactions Reaction ID Precursor Product Enzyme Reaction Type Data Source Reference
Health Effects and Bioactivity Health Outcome/Bioactivity Metabolite Response/Effect Related Health Condition Evidence Type Measured in Matrix Data Source Reference Eosinophilic esophagitis This associated disease is originally imported from HMDB metabolite HMDB0003391 concentration id 98115 Association Human Urine Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work) details
Microbial Sources Kingdom Phylum Total species Hosts and Body Sites Microbial Links Proteobacteria 182 Human Feces; Human ; Pig Unknown; Metabolic reconstruction Firmicutes 391 Human Feces; Pig ; Human ; Cattle Metabolic reconstruction Actinobacteria 128 Human Feces; Human Metabolic reconstruction Verrucomicrobia 1 Human Metabolic reconstruction Bacteroidetes 126 Human Feces; Human Metabolic reconstruction Synergistetes 4 Human Feces Metabolic reconstruction Spirochaetes 1 Human Feces Metabolic reconstruction Thaumarchaeota 1 Human Feces Metabolic reconstruction Fusobacteria 20 Human Feces; Human Metabolic reconstruction Euryarchaeota 5 Human Feces; Cattle ; Human Metabolic reconstruction Candidatus Melainabacteria 1 Human Feces Metabolic reconstruction Tenericutes 4 Human Feces Metabolic reconstruction Planctomycetes 1 Human Feces Metabolic reconstruction Crenarchaeota 1 Human Feces Metabolic reconstruction Fungi Ascomycota 1 Human Feces Unknown
Exposure Sources Source Type Source Sub-type Species Data Source Reference Details
Host Biospecimen and Location Host and Biospecimen Status Mean Std Min Max Units Age Sex Health Condition Data Source Reference Human Feces Detected but not Quantified HMDB detailsHuman Detected and Quantified 57.274 80.719 Children (1 - 13 years old) Not Specified Eosinophilic esophagitis HMDB Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work) detailsHuman Placenta Detected but not Quantified Not Specified Not Specified Normal HMDB 34986597 details
External Links HMDB ID Not Available DrugBank ID Not Available Phenol Explorer Compound ID Not Available FooDB ID Not Available KNApSAcK ID Not Available Chemspider ID Not Available KEGG Compound ID Not Available BioCyc ID Not Available BiGG ID Not Available Wikipedia Link Not Available METLIN ID Not Available PubChem Compound Not Available PDB ID Not Available ChEBI ID Not Available Food Biomarker Ontology Not Available References Synthesis Reference Not Available General References Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]
