MiMeDB: Showing metabocard for 3-Phosphoglycerate (MMDBc0029802)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:42:15 UTC

Update Date

2022-08-31 17:18:31 UTC

MiMeDB ID

MMDBc0029802

Metabolite Identification

Common Name

3-Phosphoglycerate

Description

3-phosphoglyceric acid (3PG) is a 3-carbon molecule that is a metabolic intermediate in both glycolysis and the Calvin cycle. This chemical is often termed PGA when referring to the Calvin cycle. In the Calvin cycle, two glycerate 3-phosphate molecules are reduced to form two molecules of glyceraldehyde 3-phosphate (GALP). (wikipedia)

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₃H₇O₇P

Average Molecular Weight

186.0572

Monoisotopic Molecular Weight

185.99293909

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

820-11-1

SMILES

Not Available

InChI Identifier

InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)

InChI Key

OSJPPGNTCRNQQC-UHFFFAOYSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Blood
Cellular Cytoplasm
Placenta
Prostate
Saliva
Urine

Tissue Locations

Placenta
Prostate

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76dee5cf8>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Not Available

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference
Alzheimer's disease		This associated disease is originally imported from HMDB metabolite HMDB0000807 concentration id 93543	Association	Human Saliva		23857558	details
Frontotemporal dementia		This associated disease is originally imported from HMDB metabolite HMDB0000807 concentration id 93599	Association	Human Saliva		23857558	details

Microbial Sources

Phylum	Total species	Hosts and Body Sites	Microbial Links
Proteobacteria	175	Human ; Human Feces; Pig	Unknown; Metabolic reconstruction
Firmicutes	373	Human Feces; Pig ; Human ; Cattle	Metabolic reconstruction
Actinobacteria	119	Human Feces; Human	Metabolic reconstruction
Verrucomicrobia	1	Human	Metabolic reconstruction
Bacteroidetes	116	Human Feces; Human	Metabolic reconstruction
Synergistetes	3	Human Feces	Metabolic reconstruction
Spirochaetes	1	Human Feces	Metabolic reconstruction
Thaumarchaeota	1	Human Feces	Metabolic reconstruction
Fusobacteria	19	Human Feces; Human	Metabolic reconstruction
Euryarchaeota	5	Human Feces; Cattle ; Human	Metabolic reconstruction
Candidatus Melainabacteria	1	Human Feces	Metabolic reconstruction
Tenericutes	4	Human Feces	Metabolic reconstruction
Planctomycetes	1	Human Feces	Metabolic reconstruction
Crenarchaeota	1	Human Feces	Metabolic reconstruction

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details
Animal	Milk	Bos taurus	FooDB	31437929	details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Age	Sex	Health Condition	Data Source	Reference
Human	Detected and Quantified	6.07	3.08	Adult (>18 years old)	Male	Alzheimer's disease	HMDB	23857558	details
Human	Detected and Quantified	7.73	6.31	Adult (>18 years old)	Male	Frontotemporal lobe dementia	HMDB	23857558	details
Human	Detected and Quantified	8.40	9.51	Adult (>18 years old)	Both	Lewy body disease	HMDB	23857558	details
Human	Detected and Quantified	45		Adult (>18 years old)	Both	Normal	HMDB	15882454	details
Human	Detected and Quantified	6.34	3.26	Adult (>18 years old)	Female	Normal	HMDB	23857558	details
Human	Detected and Quantified	47.2	7.4	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human	Detected and Quantified	58.2	14.4	Newborn (0-30 days old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human Placenta	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Prostate	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Urine	Detected but not Quantified			Adult (>18 years old)	Both	Normal	HMDB	28157703	details
Human Urine	Detected but not Quantified			Adult (>18 years old)	Both	Normal	HMDB	32966057	details
Human Blood	Detected but not Quantified			Adult (>18 years old)	Both	Normal	HMDB	32966057	details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Veech RL, Lawson JW, Cornell NW, Krebs HA: Cytosolic phosphorylation potential. J Biol Chem. 1979 Jul 25;254(14):6538-47. [PubMed:36399 ]
Grisolia S, Salinas M, Wallace R, Singh GK: Influence of size, protein concentration, protein synthesis inhibitors,and carbon on clearance of enzymes and proteins from blood. Physiol Chem Phys. 1976;8(1):37-52. [PubMed:183226 ]
Yu KT, Pendley C 2nd, Herczeg T, Pendleton RG: 2,3-Diphosphoglycerate phosphatase/synthase: a potential target for elevating the diphosphoglycerate level in human red blood cells. J Pharmacol Exp Ther. 1990 Jan;252(1):192-200. [PubMed:2153800 ]
Glaus M, Schneider W: Iron release from transferrin induced by mixed ligand complexes of copper(II). Biol Met. 1989;2(3):185-90. doi: 10.1007/BF01142558. [PubMed:2490073 ]
Uchida K, Mori K, Matuo Y: [Phosphoglyceric acid mutase]. Nihon Rinsho. 1995 May;53(5):1247-52. [PubMed:7602787 ]
Uchida K, Kondoh K, Matuo Y: Recombinant M-, B- and MB-type isozymes of human phosphoglyceric acid mutase: their large-scale production and preparation of polyclonal antibodies specific to M- and B-type isozymes. Clin Chim Acta. 1995 Jun 15;237(1-2):43-58. doi: 10.1016/0009-8981(95)06063-j. [PubMed:7664478 ]
Nakai A, Shigematsu Y, Liu YY, Kikawa Y, Sudo M: Urinary sugar phosphates and related organic acids in fructose-1,6-diphosphatase deficiency. J Inherit Metab Dis. 1993;16(2):408-14. doi: 10.1007/BF00710290. [PubMed:8412001 ]
Mair J: Progress in myocardial damage detection: new biochemical markers for clinicians. Crit Rev Clin Lab Sci. 1997;34(1):1-66. doi: 10.3109/10408369709038215. [PubMed:9055056 ]
Sayed A, Matsuyama S, Inoue K, Alsina J, Cai F, Chen J, Inouye M: ATPase and GTPase activities copurifying with GTP-binding proteins in E. coli. J Mol Microbiol Biotechnol. 2000 Jul;2(3):261-3. [PubMed:10937433 ]
Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18. doi: 10.1186/1742-4682-2-18. [PubMed:15882454 ]
Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
Sun Q, Li S, Wang Y, Peng H, Zhang X, Zheng Y, Li C, Li L, Chen R, Chen X, Bai W, Jiang X, Liu L, Wei F, Wang B, Zhang Y, Li H, Ren X, Zhang H: Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosis. Cell Death Differ. 2018 Jun;25(6):1160-1173. doi: 10.1038/s41418-017-0034-y. Epub 2018 Jan 23. [PubMed:29362480 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]
Mayo Medical Laboratories 2005 Test Catalog [Link]

Showing metabocard for 3-Phosphoglycerate (MMDBc0029802)

MOL for #<Metabolite:0x000055b76de4a618>

3D MOL for #<Metabolite:0x000055b76de4a618>

3D SDF for #<Metabolite:0x000055b76de4a618>

3D-SDF for #<Metabolite:0x000055b76de4a618>

PDB for #<Metabolite:0x000055b76de4a618>

3D PDB for #<Metabolite:0x000055b76de4a618>

SMILES for #<Metabolite:0x000055b76de4a618>

INCHI for #<Metabolite:0x000055b76de4a618>

Structure for #<Metabolite:0x000055b76de4a618>

3D Structure for #<Metabolite:0x000055b76de4a618>