MiMeDB: Showing metabocard for 2-Hydroxymalonate (MMDBc0030120)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:54:42 UTC

Update Date

2022-08-31 17:39:52 UTC

MiMeDB ID

MMDBc0030120

Metabolite Identification

Common Name

2-Hydroxymalonate

Description

2-hydroxymalonate is a member of the chemical class known as Sugar Acids and Derivatives. These are compounds containing a saccharide unit which bears a carboxylic acid group. 2-hydroxymalonate is involved in d-glycerate biosynthesis. Further evidence for identification as tartronate semialdehyde reductase is the observation that the coding region for this protein is directly preceded by genes coding for hydroxypyruvate isomerase and glyoxylate carboligase, two enzymes that synthesize tartronate semialdehyde, producing an operon clearly designed for d-glycerate biosynthesis from tartronate semialdehyde. (PMID 10978349 )

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₃H₂O₅

Average Molecular Weight

118.045

Monoisotopic Molecular Weight

117.990223174

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

80-69-3

SMILES

Not Available

InChI Identifier

InChI=1S/C3H4O5/c4-1(2(5)6)3(7)8/h1,4H,(H,5,6)(H,7,8)/p-2

InChI Key

ROBFUDYVXSDBQM-UHFFFAOYSA-L

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Not Available

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Proteobacteria	1	Human	Unknown

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Njau RK, Herndon CA, Hawes JW: Novel beta -hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae. J Biol Chem. 2000 Dec 8;275(49):38780-6. doi: 10.1074/jbc.M007432200. [PubMed:10978349 ]
van der Werf MJ, Overkamp KM, Muilwijk B, Coulier L, Hankemeier T: Microbial metabolomics: toward a platform with full metabolome coverage. Anal Biochem. 2007 Nov 1;370(1):17-25. doi: 10.1016/j.ab.2007.07.022. Epub 2007 Aug 1. [PubMed:17765195 ]
Keseler IM, Collado-Vides J, Santos-Zavaleta A, Peralta-Gil M, Gama-Castro S, Muniz-Rascado L, Bonavides-Martinez C, Paley S, Krummenacker M, Altman T, Kaipa P, Spaulding A, Pacheco J, Latendresse M, Fulcher C, Sarker M, Shearer AG, Mackie A, Paulsen I, Gunsalus RP, Karp PD: EcoCyc: a comprehensive database of Escherichia coli biology. Nucleic Acids Res. 2011 Jan;39(Database issue):D583-90. doi: 10.1093/nar/gkq1143. Epub 2010 Nov 21. [PubMed:21097882 ]
Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M: KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2012 Jan;40(Database issue):D109-14. doi: 10.1093/nar/gkr988. Epub 2011 Nov 10. [PubMed:22080510 ]

Showing metabocard for 2-Hydroxymalonate (MMDBc0030120)

MOL for #<Metabolite:0x000055b76e0fb790>

3D MOL for #<Metabolite:0x000055b76e0fb790>

3D SDF for #<Metabolite:0x000055b76e0fb790>

3D-SDF for #<Metabolite:0x000055b76e0fb790>

PDB for #<Metabolite:0x000055b76e0fb790>

3D PDB for #<Metabolite:0x000055b76e0fb790>

SMILES for #<Metabolite:0x000055b76e0fb790>

INCHI for #<Metabolite:0x000055b76e0fb790>

Structure for #<Metabolite:0x000055b76e0fb790>

3D Structure for #<Metabolite:0x000055b76e0fb790>