Showing metabocard for Se-Methylselenocysteine (MMDBc0030225)
Record Information
Version
1.0
Status
Detected and Quantified
Creation Date
2021-11-17 23:59:05 UTC
Update Date
2022-08-31 17:40:48 UTC
MiMeDB ID
MMDBc0030225
Metabolite Identification
Common Name
Se-Methylselenocysteine
Description
Se-Methylselenocysteine (SeMSC) is a naturally occurring seleno-amino acid that is synthesized by plants such as garlic, astragalus, onions and broccoli. SeMSC is an intermediate in selenoamino acid metabolism. Unlike selenomethionine, which is incorporated into proteins in place of methionine, SeMSC is not incorporated into any proteins, thereby being fully available for the synthesis of selenium-containing enzymes such as glutathione peroxidase.
Whanger PD: Selenium and its relationship to cancer: an update. Br J Nutr. 2004 Jan;91(1):11-28. doi: 10.1079/bjn20031015. [PubMed:14748935 ]
Yin MB, Li ZR, Cao S, Durrani FA, Azrak RG, Frank C, Rustum YM: Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression. Mol Pharmacol. 2004 Jul;66(1):153-60. doi: 10.1124/mol.66.1.153. [PubMed:15213307 ]
Duke, James A. (1992). Duke, James A. (1992) Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.. Boca Raton, FL. CRC Press..
