Showing metabocard for Inorganic phosphate (MMDBc0030348)
Record Information
Version
1.0
Status
Detected and Quantified
Creation Date
2021-11-18 00:04:38 UTC
Update Date
2022-08-31 17:44:05 UTC
MiMeDB ID
MMDBc0030348
Metabolite Identification
Common Name
Inorganic phosphate
Description
Phosphates are important in biochemistry and biogeochemistry or ecology. In ecology, because of its important role in biological systems, phosphate is a highly sought after resource. Once used, it is often a limiting nutrient in environments, and its availability may govern the rate of growth of organisms. In biological systems, phosphorus is found as a free phosphate ion in solution and is called inorganic phosphate, to distinguish it from phosphates bound in various phosphate esters. Inorganic phosphate is generally denoted Pi, and at physiological (neutral) pH primarily consists of a mixture of HPO4(2-) and H2PO4(-) ions. Phosphates in cells are most commonly found in the form of adenosine phosphates (AMP, ADP and ATP) and in DNA and RNA and can be released by the hydrolysis of ATP or ADP. In addition, the addition and removal of phosphate from proteins in all cells (by kinases and phosphatases) is a pivotal strategy in the regulation of metabolic processes. (Wikipedia ) Because the addition and removal of phosphates to and from biochemical compounds is so common, inorganic phosphate (Pi) is involved in a huge number of reactions in E. coli. Also, many E. coli enzymes are activated or inhibited by phosphate. (EcoCyc) Some processes that phosphates (Pi) are involved with in E. coli are oxidative phosphorylation, where a phosphate is added to ADP to make ATP, and biosynthesis of peptidoglycan, a component of bacterial cell walls. (KEGG)
Belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion.
Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Drager A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlic A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO: Recon3D enables a three-dimensional view of gene variation in human metabolism. Nat Biotechnol. 2018 Mar;36(3):272-281. doi: 10.1038/nbt.4072. Epub 2018 Feb 19. [PubMed:29457794 ]
