MiMeDB: Showing metabocard for Molybdenum (MMDBc0030350)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-18 00:04:46 UTC

Update Date

2022-08-31 17:44:07 UTC

Metabolite ID

MMDBc0030350

Metabolite Identification

Common Name

Molybdenum

Description

Molybdenum is a transition metal with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. The pure metal is silvery white in color, fairly soft, and has one of the highest melting points of all pure elements. Physiologically, it exists as an ion. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. There is a trace requirement for molybdenum in plants, and soils can be barren due to molybdenum deficiencies. Plants and animals generally have molybdenum present in amounts of a few parts per million. In small quantities, molybdenum is effective at hardening steel. Molybdenum is important in plant nutrition, and is found in certain enzymes, including xanthine oxidase. Molybdenum is used to this day in high-strength alloys and in high-temperature steels. Special molybdenum-containing alloys, such as the Hastelloys, are notably heat-resistant and corrosion-resistant. Molybdenum is used in oil pipelines, aircraft and missile parts, and in filaments. Molybdenum finds use as a catalyst in the petroleum industry, especially in catalysts for removing organic sulfurs from petroleum products. It is used to form the anode in some x-ray tubes, particularly in mammography applications. And is found in some electronic applications as the conductive metal layers in thin-film transistors (TFTs). Molybdenum disulfide is a good lubricant, especially at high temperatures. And Mo-99 is used in the nuclear isotope industry. Molybdenum pigments range from red-yellow to a bright red orange and are used in paints, inks, plastics, and rubber compounds.‚Üµ

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Mo	HMDB
Molybdaen	HMDB
Molybdene	HMDB
Molybdenum atom	HMDB
Molybdenum elemental	HMDB
Molybdenum insoluble compounds	HMDB
Molybdenum metallic	HMDB

Molecular Formula

Average Mass

95.94

Monoisotopic Mass

97.905407846

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

7439-98-7

SMILES

Not Available

InChI Identifier

InChI=1S/Mo/q+2

InChI Key

MMVYPOCJESWGTC-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous transition metal compounds

Sub Class

Not Available

Direct Parent

Homogeneous transition metal compounds

Alternative Parents

Not Available

Substituents

Homogeneous transition metal

Molecular Framework

Not Available

External Descriptors

a cation (MO+2 )

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Blood
Brain
Cerebrospinal Fluid (CSF)
Saliva
Urine

Tissue Locations

Brain

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191797	Aldehyde oxidase	Unknown	Q06278	Homo_sapiens
MMDBp0191852	Xanthine dehydrogenase/oxidase	Unknown	P47989	Homo_sapiens
MMDBp0192666	Sulfite oxidase, mitochondrial	Unknown	P51687	Homo_sapiens
MMDBp0193716	Gephyrin	Unknown	Q9NQX3	Homo_sapiens
MMDBp0195652	MOSC domain-containing protein 2, mitochondrial	Enzyme	Q969Z3	Homo_sapiens
MMDBp0195727	Molybdenum cofactor sulfurase	Enzyme	Q96EN8	Homo_sapiens
MMDBp0196273	MOSC domain-containing protein 1, mitochondrial	Enzyme	Q5VT66	Homo_sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Alzheimer's disease	Slight Increase	Association	Human Blood	HMDB	16244393
Multiple sclerosis	Increased	Association	Human Blood	HMDB	16244395
Parkinson's disease	Slight Increase	Association	Human Blood	HMDB	16244392

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	1	Human ; Human feces; Human feces; pleural fluid plaque; bal	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human	Detected and Quantified	0.012	0.0059			Elderly (>65 years old)	Both	Alzheimer's disease	HMDB	16244393
Human	Detected and Quantified	0.022	0.0085			Adult (>18 years old)	Both	Multiple sclerosis	HMDB	16244395
Human	Detected and Quantified	0.0091	0.0043			Adult (>18 years old)	Both	Parkinson's disease	HMDB	16244392
Human	Detected and Quantified	0.00146	0.000834			Adult (>18 years old)	Male	Normal	HMDB	20604873
Human	Detected and Quantified	0.00219	0.00125			Adult (>18 years old)	Male	Normal	HMDB	20604873
Human	Detected and Quantified	0.00302	0.00250			Adult (>18 years old)	Male	Normal	HMDB	20604873
Human	Detected and Quantified	0.00365	0.00292			Adult (>18 years old)	Male	Normal	HMDB	20604873
Human	Detected and Quantified	0.0094	0.005			Elderly (>65 years old)	Both	Normal	HMDB	16244393
Human	Detected and Quantified	0.01	0.009			Adult (>18 years old)	Both	Normal	HMDB	1641639
Human	Detected and Quantified	0.034	0.016			Adult (>18 years old)	Not Specified	Normal	HMDB	22546835
Human	Detected and Quantified	0.049		0.006	0.295	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human	Detected and Quantified			0.0029	0.0120	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	0.006		0.0029	0.012	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	0.06	0.03			Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human	Detected and Quantified	0.0494		0.0471	0.0517	Adult (>18 years old)	Not Specified	Normal	HMDB	National Health and Nutrition Examination Survey (NHANES Survey) 2013
Human	Detected and Quantified	0.104		0.0965	0.113	Children (1-13 years old)	Not Specified	Normal	HMDB	National Health and Nutrition Examination Survey (NHANES Survey) 2013
Human	Detected and Quantified	0.00766		0.00684	0.00889	Adult (>18 years old)	Both	Normal	HMDB	Report on Human Biomonitoring of Environmental Chemicals in Canada (2010). ISBN 978-1-100-15618-7. Cat no. H128-1/10-601E
Human	Detected and Quantified	0.00940		0.00705	0.01461		Both	Normal	HMDB	Report on Human Biomonitoring of Environmental Chemicals in Canada (2010). ISBN 978-1-100-15618-7. Cat no. H128-1/10-601E
Human	Detected and Quantified	0.05728		0.05035	0.06374	Adult (>18 years old)	Both	Normal	HMDB	Report on Human Biomonitoring of Environmental Chemicals in Canada (2010). ISBN 978-1-100-15618-7. Cat no. H128-1/10-601E
Human	Detected and Quantified	0.09030		0.05809	0.12183		Both	Normal	HMDB	Report on Human Biomonitoring of Environmental Chemicals in Canada (2010). ISBN 978-1-100-15618-7. Cat no. H128-1/10-601E
Human	Detected and Quantified	0.035	0.02			Adult (>18 years old)	Both	Normal	HMDB	https://doi.org/10.1007/s11306-015-0840-5
Human	Detected and Quantified			0.14	0.17	Not Specified	Both	Molybdenum Exposure	HMDB	National Health and Nutrition Examination Survey (NHANES Survey) 2019
Human	Detected and Quantified			0.13	0.15	Not Specified	Both	Molybdenum Exposure	HMDB	National Health and Nutrition Examination Survey (NHANES Survey) 2019
Human	Detected and Quantified			0.13	0.15	Not Specified	Both	Molybdenum Exposure	HMDB	National Health and Nutrition Examination Survey (NHANES Survey) 2019
Human Brain	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597

External Links

HMDB ID

HMDB0001302

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB003653

KNApSAcK ID

Not Available

Chemspider ID

161267

KEGG Compound ID

C00150

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Molybdenum

METLIN ID

Not Available

PubChem Compound

185498

PDB ID

Not Available

ChEBI ID

28685

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Schmidt M, Weber H, Schon R: Cobalt chromium molybdenum metal combination for modular hip prostheses. Clin Orthop Relat Res. 1996 Aug;(329 Suppl):S35-47. doi: 10.1097/00003086-199608001-00004. [PubMed:8769321 ]
Kisker C, Schindelin H, Rees DC: Molybdenum-cofactor-containing enzymes: structure and mechanism. Annu Rev Biochem. 1997;66:233-67. doi: 10.1146/annurev.biochem.66.1.233. [PubMed:9242907 ]
Nakagawa N: [Studies on changes in trace elements of the brain related to aging]. Hokkaido Igaku Zasshi. 1998 Mar;73(2):181-99. [PubMed:9612711 ]
Kisker C, Schindelin H, Baas D, Retey J, Meckenstock RU, Kroneck PM: A structural comparison of molybdenum cofactor-containing enzymes. FEMS Microbiol Rev. 1998 Dec;22(5):503-21. doi: 10.1111/j.1574-6976.1998.tb00384.x. [PubMed:9990727 ]
Vyskocil A, Viau C: Assessment of molybdenum toxicity in humans. J Appl Toxicol. 1999 May-Jun;19(3):185-92. doi: 10.1002/(sici)1099-1263(199905/06)19:3<185::aid-jat555>3.0.co;2-z. [PubMed:10362269 ]
Barceloux DG: Molybdenum. J Toxicol Clin Toxicol. 1999;37(2):231-7. doi: 10.1081/clt-100102422. [PubMed:10382558 ]
Failla ML: Considerations for determining 'optimal nutrition' for copper, zinc, manganese and molybdenum. Proc Nutr Soc. 1999 May;58(2):497-505. doi: 10.1017/s0029665199000646. [PubMed:10466195 ]
Reiss J: Genetics of molybdenum cofactor deficiency. Hum Genet. 2000 Feb;106(2):157-63. doi: 10.1007/s004390051023. [PubMed:10746556 ]
Williams RJ, Frausto da Silva JJ: The involvement of molybdenum in life. Biochem Biophys Res Commun. 2002 Mar 29;292(2):293-9. doi: 10.1006/bbrc.2002.6518. [PubMed:11906160 ]
Hille R: Molybdenum and tungsten in biology. Trends Biochem Sci. 2002 Jul;27(7):360-7. doi: 10.1016/s0968-0004(02)02107-2. [PubMed:12114025 ]
Johnson JL: Prenatal diagnosis of molybdenum cofactor deficiency and isolated sulfite oxidase deficiency. Prenat Diagn. 2003 Jan;23(1):6-8. doi: 10.1002/pd.505. [PubMed:12533804 ]
Reiss J, Johnson JL: Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH. Hum Mutat. 2003 Jun;21(6):569-76. doi: 10.1002/humu.10223. [PubMed:12754701 ]
Goldhaber SB: Trace element risk assessment: essentiality vs. toxicity. Regul Toxicol Pharmacol. 2003 Oct;38(2):232-42. doi: 10.1016/s0273-2300(02)00020-x. [PubMed:14550763 ]
Hille R: Molybdenum-containing hydroxylases. Arch Biochem Biophys. 2005 Jan 1;433(1):107-16. doi: 10.1016/j.abb.2004.08.012. [PubMed:15581570 ]
Mendel RR: Molybdenum: biological activity and metabolism. Dalton Trans. 2005 Nov 7;(21):3404-9. doi: 10.1039/b505527j. Epub 2005 Sep 26. [PubMed:16234918 ]
Schwarz G: Molybdenum cofactor biosynthesis and deficiency. Cell Mol Life Sci. 2005 Dec;62(23):2792-810. doi: 10.1007/s00018-005-5269-y. [PubMed:16261263 ]
Kitamura S, Sugihara K, Ohta S: Drug-metabolizing ability of molybdenum hydroxylases. Drug Metab Pharmacokinet. 2006 Apr;21(2):83-98. doi: 10.2133/dmpk.21.83. [PubMed:16702728 ]
Mendel RR, Bittner F: Cell biology of molybdenum. Biochim Biophys Acta. 2006 Jul;1763(7):621-35. doi: 10.1016/j.bbamcr.2006.03.013. Epub 2006 May 12. [PubMed:16784786 ]
Enemark JH, Astashkin AV, Raitsimring AM: Investigation of the coordination structures of the molybdenum(v) sites of sulfite oxidizing enzymes by pulsed EPR spectroscopy. Dalton Trans. 2006 Aug 7;(29):3501-14. doi: 10.1039/b602919a. Epub 2006 Jun 22. [PubMed:16855750 ]

Showing metabocard for Molybdenum (MMDBc0030350)

MOL for #<Metabolite:0x00007f1240e8a810>

3D MOL for #<Metabolite:0x00007f1240e8a810>

3D SDF for #<Metabolite:0x00007f1240e8a810>

3D-SDF for #<Metabolite:0x00007f1240e8a810>

PDB for #<Metabolite:0x00007f1240e8a810>

3D PDB for #<Metabolite:0x00007f1240e8a810>

SMILES for #<Metabolite:0x00007f1240e8a810>

INCHI for #<Metabolite:0x00007f1240e8a810>

Structure for #<Metabolite:0x00007f1240e8a810>

3D Structure for #<Metabolite:0x00007f1240e8a810>