Record Information Version 1.0 Status Detected and Quantified Creation Date 2021-11-18 00:04:54 UTC Update Date 2022-08-31 17:44:09 UTC MiMeDB ID MMDBc0030353 Metabolite Identification Common Name Lithium Description Lithium (Li) is an alkali metal with atomic number 3. Trace amounts of lithium are present in all organisms, though the element serves no apparent vital biological function. (Wikipedia ) Scientific research has suggested that lithium is an inhibitor of several E. coli enzymes, such as L-rhamnulose-1-phosphate aldolase. (EcoCyc) Structure Synonyms Value Source Li(+) ChEBI Lithium cation ChEBI LITHIUM ion ChEBI Lithium, ion ChEBI Lithium, ion (li1+) ChEBI Li HMDB Li(+) cation HMDB Li(+) ion HMDB Lithium atom HMDB Lithium element HMDB
Chemical Formula Li Average Molecular Weight 6.941 Monoisotopic Molecular Weight 7.016004049 IUPAC Name Not Available Traditional Name Not Available CAS Registry Number 7439-93-2 SMILES Not Available InChI Identifier InChI=1S/Li/q+1
InChI Key HBBGRARXTFLTSG-UHFFFAOYSA-N Chemical Taxonomy Description Belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. Kingdom Inorganic compounds Super Class Homogeneous metal compounds Class Homogeneous alkali metal compounds Sub Class Not Available Direct Parent Homogeneous alkali metal compounds Alternative Parents Not Available Substituents Molecular Framework Not Available External Descriptors Functional Ontology Not Available Physical Properties State Solid Predicted Properties Not Available Spectra Not Available Biological Properties Cellular Locations Not Available Biospecimen Locations Blood
Cerebrospinal Fluid (CSF)
Feces
Saliva
Urine Tissue Locations Not Available Associated OMIM IDs 114500 (Colorectal cancer)610247 (Eosinophilic esophagitis)Human Proteins and Enzymes Proteins #<MetaboliteProteinLink:0x000055b76ddb1080> Human Pathways Pathways Metabolic Reactions Reaction ID Precursor Product Enzyme Reaction Type Data Source Reference
Health Effects and Bioactivity Health Outcome/Bioactivity Metabolite Response/Effect Related Health Condition Evidence Type Measured in Matrix Data Source Reference Alzheimer's disease This associated disease is originally imported from HMDB metabolite HMDB0005949 concentration id 17907 Association Human Blood 16244393 detailsMultiple sclerosis This associated disease is originally imported from HMDB metabolite HMDB0005949 concentration id 17953 Association Human Blood 16244395 detailsParkinson's disease Slight Decrease This associated disease is originally imported from HMDB metabolite HMDB0005949 concentration id 18214 Association Human Blood 16244392 details
Microbial Sources Kingdom Phylum Total species Hosts and Body Sites Microbial Links Proteobacteria 2 Human Unknown;
Exposure Sources Source Type Source Sub-type Species Data Source Reference Details
Host Biospecimen and Location Host and Biospecimen Status Mean Std Min Max Units Age Sex Health Condition Data Source Reference Human Feces Detected but not Quantified HMDB detailsHuman Detected and Quantified 0.16 0.074 Elderly (>65 years old) Both Alzheimer's disease HMDB 16244393 detailsHuman Detected and Quantified 0.12 0.05 Adult (>18 years old) Both Multiple sclerosis HMDB 16244395 detailsHuman Detected and Quantified 0.11 0.085 Adult (>18 years old) Both Parkinson's disease HMDB 16244392 detailsHuman Detected and Quantified 0.040 0.240 Adult (>18 years old) Both Normal HMDB 16244392 detailsHuman Detected and Quantified 0.14 0.10 Adult (>18 years old) Both Normal HMDB 16244392 detailsHuman Detected and Quantified 0.5 0.2 0.9 Adult (>18 years old) Both Normal HMDB 24023812 detailsHuman Detected and Quantified 0.504 0.058 3.414 Adult (>18 years old) Not Specified Normal HMDB 16248993 detailsHuman Detected and Quantified 10.383 4.679 Adult (>18 years old) Not Specified Normal HMDB 22546835 detailsHuman Detected and Quantified 92.206 1844.115 Adult (>18 years old) Not Specified Normal HMDB 5256500 detailsHuman Detected and Quantified 2.537 0.793 Adult (>18 years old) Both Normal HMDB Zerihun T. Dame, Farid Aziat, Rupasri Mandal, Ram Krishnamurthy, Souhaila Bouatra, Shima Borzouie, An Chi Guo, Tanvir Sajed, Lu Deng, Hong Lin, Philip Liu, Edison Dong, David S. Wishart "The human saliva metabolome" Metabolomics (2015) DOI 10.1007/s11306-015-0840-5 details
External Links HMDB ID HMDB0005949 DrugBank ID DB01356 Phenol Explorer Compound ID Not Available FooDB ID FDB004181 KNApSAcK ID Not Available Chemspider ID 26502 KEGG Compound ID C15473 BioCyc ID LI%2b BiGG ID Not Available Wikipedia Link Lithium METLIN ID Not Available PubChem Compound 28486 PDB ID LI ChEBI ID 49713 Food Biomarker Ontology Not Available References Synthesis Reference Not Available General References Kofman O, Belmaker RH: Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression. Biol Psychiatry. 1993 Dec 15;34(12):839-52. doi: 10.1016/0006-3223(93)90052-f. [PubMed:8110911 ] Waring WS: Management of lithium toxicity. Toxicol Rev. 2006;25(4):221-30. doi: 10.2165/00139709-200625040-00003. [PubMed:17288494 ] Aghdam SY, Barger SW: Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium. Curr Alzheimer Res. 2007 Feb;4(1):21-31. doi: 10.2174/156720507779939832. [PubMed:17316163 ] Zhong J, Lee WH: Lithium: a novel treatment for Alzheimer's disease? Expert Opin Drug Saf. 2007 Jul;6(4):375-83. doi: 10.1517/14740338.6.4.375. [PubMed:17688381 ] Quiroz JA, Machado-Vieira R, Zarate CA Jr, Manji HK: Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects. Neuropsychobiology. 2010;62(1):50-60. doi: 10.1159/000314310. Epub 2010 May 7. [PubMed:20453535 ]
