MiMeDB: Showing metabocard for Adenosine tetraphosphate (MMDBc0030369)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-18 00:05:35 UTC

Update Date

2022-08-31 17:49:50 UTC

MiMeDB ID

MMDBc0030369

Metabolite Identification

Common Name

Adenosine tetraphosphate

Description

Adenosine 5' tetraphosphate, Ap4, is a natural nucleotide present in many biological systems. Technically adenosine tetraphosphate is condensation product of adenosine with tetraphosphoric acid at the 5' position. Acetyl coenzyme A (CoA) synthetase (EC 6.2.1.1) catalyzes the synthesis of adenosine 5'-tetraphosphate (P4A) and adenosine 5'-pentaphosphate (p5A) from ATP and tri- or tetrapolyphosphate (P3 or P4). [PMID:9620965 ]

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₁₀H₁₇N₅O₁₆P₄

Average Molecular Weight

587.1609

Monoisotopic Molecular Weight

586.962075569

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

58337-43-2

SMILES

Not Available

InChI Identifier

InChI=1S/C10H17N5O16P4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(28-10)1-27-33(21,22)30-35(25,26)31-34(23,24)29-32(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H,25,26)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI Key

WWMWAMFHUSTZTA-KQYNXXCUSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Adrenal Medulla
Placenta
Spleen

Tissue Locations

Adrenal Medulla
Placenta
Spleen

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76e0d6828>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Proteobacteria	1	Human	Unknown
Fungi	Ascomycota	2

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Age	Sex	Health Condition	Data Source	Reference
Human Adrenal Medulla	Detected but not Quantified	Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Placenta	Detected but not Quantified	Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Spleen	Detected but not Quantified	Not Specified	Not Specified	Normal	HMDB	34986597	details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Luthje J, Baringer J, Ogilvie A: Effects of diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) on platelet aggregation in unfractionated human blood. Blut. 1985 Dec;51(6):405-13. doi: 10.1007/BF00320727. [PubMed:3852686 ]
Sillero MA, Del Valle M, Zaera E, Michelena P, Garcia AG, Sillero A: Diadenosine 5',5"-P1,P4-tetraphosphate (Ap4A), ATP and catecholamine content in bovine adrenal medulla, chromaffin granules and chromaffin cells. Biochimie. 1994;76(5):404-9. doi: 10.1016/0300-9084(94)90116-3. [PubMed:7849106 ]
Lazewska D, Starzynska E, Guranowski A: Human placental (Asymmetrical) diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase: purification to homogeneity and some properties. Protein Expr Purif. 1993 Feb;4(1):45-51. doi: 10.1006/prep.1993.1007. [PubMed:8381042 ]
Lee JW, Kong ID, Park KS, Jeong SW: Effects of adenosine tetraphosphate (ATPP) on vascular tone in the isolated rat aorta. Yonsei Med J. 1995 Dec;36(6):487-96. doi: 10.3349/ymj.1995.36.6.487. [PubMed:8599250 ]
Liu Q, Dumont DJ: Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen EST Program. Genomics. 1997 Jan 1;39(1):109-12. doi: 10.1006/geno.1996.4374. [PubMed:9027494 ]
Pintor J, Peral A, Hoyle CH, Redick C, Douglass J, Sims I, Yerxa B: Effects of diadenosine polyphosphates on tear secretion in New Zealand white rabbits. J Pharmacol Exp Ther. 2002 Jan;300(1):291-7. doi: 10.1124/jpet.300.1.291. [PubMed:11752128 ]
Pintor J, Carracedo G, Alonso MC, Bautista A, Peral A: Presence of diadenosine polyphosphates in human tears. Pflugers Arch. 2002 Jan;443(3):432-6. doi: 10.1007/s004240100696. Epub 2001 Aug 23. [PubMed:11810214 ]
Pintor J, Pelaez T, Peral A: Adenosine tetraphosphate, Ap4, a physiological regulator of intraocular pressure in normotensive rabbit eyes. J Pharmacol Exp Ther. 2004 Feb;308(2):468-73. doi: 10.1124/jpet.103.058669. Epub 2003 Nov 4. [PubMed:14600249 ]

Showing metabocard for Adenosine tetraphosphate (MMDBc0030369)

MOL for #<Metabolite:0x000055b76dee73f0>

3D MOL for #<Metabolite:0x000055b76dee73f0>

3D SDF for #<Metabolite:0x000055b76dee73f0>

3D-SDF for #<Metabolite:0x000055b76dee73f0>

PDB for #<Metabolite:0x000055b76dee73f0>

3D PDB for #<Metabolite:0x000055b76dee73f0>

SMILES for #<Metabolite:0x000055b76dee73f0>

INCHI for #<Metabolite:0x000055b76dee73f0>

Structure for #<Metabolite:0x000055b76dee73f0>

3D Structure for #<Metabolite:0x000055b76dee73f0>