MiMeDB: Showing metabocard for NMN (MMDBc0031158)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-18 00:37:42 UTC

Update Date

2022-08-31 17:58:58 UTC

MiMeDB ID

MMDBc0031158

Metabolite Identification

Common Name

NMN

Description

3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₁₁H₁₆N₂O₈P

Average Molecular Weight

335.2271

Monoisotopic Molecular Weight

335.06442701

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

1094-61-7

SMILES

Not Available

InChI Identifier

InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/p+1/t7-,8-,9-,11-/m1/s1

InChI Key

DAYLJWODMCOQEW-TURQNECASA-O

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Mitochondria
Nucleus

Biospecimen Locations

Blood
Placenta
Urine

Tissue Locations

Placenta

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76a651a18>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Phylum	Total species	Hosts and Body Sites	Microbial Links
Proteobacteria	251	Human ; Human Feces; Pig	Unknown; Metabolic reconstruction
Firmicutes	427	Human Feces; Pig ; Human ; Cattle	Metabolic reconstruction
Actinobacteria	121	Human Feces; Human	Metabolic reconstruction
Verrucomicrobia	1	Human	Metabolic reconstruction
Bacteroidetes	120	Human Feces; Human	Metabolic reconstruction
Synergistetes	3	Human Feces	Metabolic reconstruction
Spirochaetes	2	Human Feces	Metabolic reconstruction
Thaumarchaeota	1	Human Feces	Metabolic reconstruction
Fusobacteria	6	Human Feces; Human	Metabolic reconstruction
Euryarchaeota	5	Human Feces; Cattle ; Human	Metabolic reconstruction
Candidatus Melainabacteria	2	Human Feces	Metabolic reconstruction
Tenericutes	3	Human Feces	Metabolic reconstruction
Planctomycetes	1	Human Feces	Metabolic reconstruction
Crenarchaeota	1	Human Feces	Metabolic reconstruction

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human	Detected and Quantified	133.33	600	Adult (>18 years old)	Both	Sodium nitrate consumption	HMDB	7618150	details
Human	Detected and Quantified	66.67	133.33	Adult (>18 years old)	Both	Normal	HMDB	7618150	details
Human Placenta	Detected but not Quantified			Not Specified	Not Specified	Normal	HMDB	34986597	details
Human	Detected but not Quantified						HMDB		details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Schuberth J: Volatile compounds detected in blood of drunk drivers by headspace/capillary gas chromatography/ion trap mass spectrometry. Biol Mass Spectrom. 1991 Nov;20(11):699-702. doi: 10.1002/bms.1200201108. [PubMed:1799580 ]
Emanuelli M, Raffaelli N, Amici A, Balducci E, Natalini P, Ruggieri S, Magni G: The antitumor drug, 1,3-bis(2-chloroethyl)-1-nitroso-urea, inactivates human nicotinamide mononucleotide adenylyltransferase. Biochem Pharmacol. 1995 Feb 14;49(4):575-9. doi: 10.1016/0006-2952(94)00478-5. [PubMed:7872964 ]
Ohdoi C, Nyhan WL, Kuhara T: Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):123-30. doi: 10.1016/s1570-0232(03)00277-0. [PubMed:12829005 ]
Magni G, Amici A, Emanuelli M, Orsomando G, Raffaelli N, Ruggieri S: Structure and function of nicotinamide mononucleotide adenylyltransferase. Curr Med Chem. 2004 Apr;11(7):873-85. doi: 10.2174/0929867043455666. [PubMed:15078171 ]
Moriya F, Hashimoto Y: Postmortem production of ethanol and n-propanol in the brain of drowned persons. Am J Forensic Med Pathol. 2004 Jun;25(2):131-3. doi: 10.1097/01.paf.0000127402.97576.42. [PubMed:15166764 ]
Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S: Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab. 2007 Nov;6(5):363-75. doi: 10.1016/j.cmet.2007.09.003. [PubMed:17983582 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for NMN (MMDBc0031158)

MOL for #<Metabolite:0x000055b76e275710>

3D MOL for #<Metabolite:0x000055b76e275710>

3D SDF for #<Metabolite:0x000055b76e275710>

3D-SDF for #<Metabolite:0x000055b76e275710>

PDB for #<Metabolite:0x000055b76e275710>

3D PDB for #<Metabolite:0x000055b76e275710>

SMILES for #<Metabolite:0x000055b76e275710>

INCHI for #<Metabolite:0x000055b76e275710>

Structure for #<Metabolite:0x000055b76e275710>

3D Structure for #<Metabolite:0x000055b76e275710>