MiMeDB: Showing metabocard for Protein tyrosine (MMDBc0031933)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-18 01:55:35 UTC

Update Date

2022-08-31 18:26:34 UTC

MiMeDB ID

MMDBc0031933

Metabolite Identification

Common Name

Protein tyrosine

Description

NULL

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₀H₃₂O₅

Average Molecular Weight

352.4651

Monoisotopic Molecular Weight

352.224974134

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1

InChI Key

XEYBRNLFEZDVAW-ARSRFYASSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Endoplasmic reticulum
Extracellular
Membrane

Biospecimen Locations

Blood
Brain
Cerebrospinal Fluid (CSF)
Epidermis
Feces
Fibroblasts
Placenta
Urine

Tissue Locations

Brain
Epidermis
Fibroblasts
Placenta

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x00007f09200f1380>

Human Pathways

Pathways

Name	SMPDB/PathBank
Succinate Signalling During Inflammation

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Related Health Condition	Evidence Type	Measured in Matrix	Reference
Amyotrophic lateral sclerosis	This associated disease is originally imported from HMDB metabolite HMDB0001220 concentration id 6724	Association	Human Cerebrospinal Fluid (CSF)	11971099	details
Hydrocephalus	This associated disease is originally imported from HMDB metabolite HMDB0001220 concentration id 61731	Association	Human Cerebrospinal Fluid (CSF)	2835791	details
Meningitis	This associated disease is originally imported from HMDB metabolite HMDB0001220 concentration id 61732	Association	Human Cerebrospinal Fluid (CSF)	2835791	details

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Proteobacteria	1	Human	Unknown

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified								HMDB		details
Human	Detected and Quantified	35.0	10.0			Adult (>18 years old)	Not Specified	Amyotrophic lateral sclerosis	HMDB	11971099	details
Human	Detected and Quantified	0.00006246	0.000165			Not Specified	Not Specified	hydrocephalus	HMDB	2835791	details
Human	Detected and Quantified	0.00716		0.000116	0.0142	Not Specified	Not Specified	meningitis	HMDB	2835791	details
Human	Detected and Quantified	<0.00005110				Adult (>18 years old)	Both	Normal	HMDB	6593432	details
Human	Detected and Quantified			0	0.02	Adult (>18 years old)	Both	Normal	HMDB	11971099	details
Human	Detected and Quantified	0.000037	0.000012			Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.0000967	0.000012			Adult (>18 years old)	Both	Normal	HMDB	21359215	details
Human	Detected and Quantified	0.000172	0.00013			Adult (>18 years old)	Both	Normal	HMDB	21359215	details
Human	Detected and Quantified	0.0002	0.0002			Newborn (0-30 days old)	Both	Normal	HMDB	24817352	details
Human	Detected and Quantified	0.0009	0.000060			Adult (>18 years old)	Female	Normal	HMDB	12840179	details
Human	Detected and Quantified	0.001	0.000053			Adult (>18 years old)	Male	Normal	HMDB	12840179	details
Human	Detected and Quantified	0.00218	0.00287			Adult (>18 years old)	Both	Normal	HMDB	18953024	details
Human	Detected and Quantified	0.00218	0.00287			Adult (>18 years old)	Both	Normal	HMDB	21359215	details
Human	Detected and Quantified	0.0098	0.0011			Adult (>18 years old)	Female	Normal	HMDB	9373880	details
Human	Detected and Quantified	0.015	0.002			Adult (>18 years old)	Female	Normal	HMDB	9373880	details
Human	Detected and Quantified	0.000057	0.000020			Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human	Detected and Quantified	0.00012	0.000025			Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human	Detected and Quantified	0.0013	0.0020			Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human Brain	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Epidermis	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Fibroblasts	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Placenta	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	19636438	details

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Greaves MW: Does ultraviolet-evoked prostaglandin formation protect skin from actinic cancer? Lancet. 1978 Jan 28;1(8057):189. doi: 10.1016/s0140-6736(78)90618-9. [PubMed:74611 ]
Catanzarite VA: Prophylactic intramyometrial carboprost tromethamine does not substantially reduce blood loss relative to intramyometrial oxytocin at routine cesarean section. Am J Perinatol. 1990 Jan;7(1):39-42. doi: 10.1055/s-2007-999443. [PubMed:2403792 ]
Iizuka H, Ohkawara A, Ishibashi Y: Human skin epidermal adenylate cyclase systems: defective beta-adrenergic responsiveness in the involved epidermis of Darier's disease. Curr Probl Dermatol. 1983;11:45-58. doi: 10.1159/000408663. [PubMed:6317292 ]
Schmitz T, Dallot E, Leroy MJ, Breuiller-Fouche M, Ferre F, Cabrol D: EP(4) receptors mediate prostaglandin E(2)-stimulated glycosaminoglycan synthesis in human cervical fibroblasts in culture. Mol Hum Reprod. 2001 Apr;7(4):397-402. doi: 10.1093/molehr/7.4.397. [PubMed:11279302 ]
Amato F, Rizzuto G, Nicoletti A, Senatore M, Roberti R: [Isolated peripheral arterial ischaemia and medullary neurostimulation: case report]. G Ital Nefrol. 2003 Mar-Apr;20(2):200-4. [PubMed:12746806 ]
Ilzecka J: Prostaglandin E2 is increased in amyotrophic lateral sclerosis patients. Acta Neurol Scand. 2003 Aug;108(2):125-9. doi: 10.1034/j.1600-0404.2003.00102.x. [PubMed:12859290 ]
Seo JY, Kim EK, Lee SH, Park KC, Kim KH, Eun HC, Chung JH: Enhanced expression of cylooxygenase-2 by UV in aged human skin in vivo. Mech Ageing Dev. 2003 Aug-Sep;124(8-9):903-10. doi: 10.1016/s0047-6374(03)00150-7. [PubMed:14499495 ]
Konopka T, Rutkowska M, Hirnle L, Kopec W, Karolewska E: The secretion of prostaglandin E2 and interleukin 1-beta in women with periodontal diseases and preterm low-birth-weight. Bull Group Int Rech Sci Stomatol Odontol. 2003 Jan-Apr;45(1):18-28. [PubMed:14535055 ]
Yamada M, Ogata M, Kawai M, Mashima Y, Nishida T: Substance P in human tears. Cornea. 2003 Oct;22(7 Suppl):S48-54. doi: 10.1097/00003226-200310001-00007. [PubMed:14703707 ]
Laitinen K, Arvola T, Moilanen E, Lampi AM, Ruuska T, Isolauri E: Characterization of breast milk received by infants with gross blood in stools. Biol Neonate. 2005;87(1):66-72. doi: 10.1159/000081955. Epub 2004 Nov 9. [PubMed:15542928 ]
Christidis N, Kopp S, Ernberg M: The effect on mechanical pain threshold over human muscles by oral administration of granisetron and diclofenac-sodium. Pain. 2005 Feb;113(3):265-270. doi: 10.1016/j.pain.2004.10.016. [PubMed:15661432 ]
Waschbisch A, Fiebich BL, Akundi RS, Schmitz ML, Hoozemans JJ, Candelario-Jalil E, Virtainen N, Veerhuis R, Slawik H, Yrjanheikki J, Hull M: Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. J Neurochem. 2006 Feb;96(3):680-93. doi: 10.1111/j.1471-4159.2005.03599.x. Epub 2006 Jan 9. [PubMed:16405508 ]
Choi SH, Langenbach R, Bosetti F: Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis. J Neurochem. 2006 Aug;98(3):801-11. doi: 10.1111/j.1471-4159.2006.03926.x. Epub 2006 Jun 19. [PubMed:16787416 ]
Harizi H, Gualde N: Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derived inflammatory mediators. Cell Mol Immunol. 2006 Aug;3(4):271-7. [PubMed:16978535 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for Protein tyrosine (MMDBc0031933)

MOL for #<Metabolite:0x000055b76e2023a0>

3D MOL for #<Metabolite:0x000055b76e2023a0>

3D SDF for #<Metabolite:0x000055b76e2023a0>

3D-SDF for #<Metabolite:0x000055b76e2023a0>

PDB for #<Metabolite:0x000055b76e2023a0>

3D PDB for #<Metabolite:0x000055b76e2023a0>

SMILES for #<Metabolite:0x000055b76e2023a0>

INCHI for #<Metabolite:0x000055b76e2023a0>

Structure for #<Metabolite:0x000055b76e2023a0>

3D Structure for #<Metabolite:0x000055b76e2023a0>