MiMeDB: Showing metabocard for Liothyronine (MMDBc0031978)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-18 01:57:18 UTC

Update Date

2022-08-31 18:27:06 UTC

MiMeDB ID

MMDBc0031978

Metabolite Identification

Common Name

Liothyronine

Description

NULL

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₁₅H₁₂I₃NO₄

Average Molecular Weight

650.9735

Monoisotopic Molecular Weight

650.790038137

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChI Key

AUYYCJSJGJYCDS-LBPRGKRZSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Membrane

Biospecimen Locations

Adipose Tissue
Adrenal Gland
Blood
Epidermis
Feces
Fibroblasts
Intestine
Neuron
Placenta
Platelet
Saliva
Skeletal Muscle
Testis
Thyroid Gland
Urine

Tissue Locations

Adipose Tissue
Adrenal Gland
Epidermis
Fibroblasts
Intestine
Neuron
Placenta
Platelet
Skeletal Muscle
Testis
Thyroid Gland

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x00007f09200beea8>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Reference
Anorexia nervosa	Slight Decrease	This associated disease is originally imported from HMDB metabolite HMDB0000265 concentration id 11855	Association	Human Blood	10197568	details
Hyperthyroidism		This associated disease is originally imported from HMDB metabolite HMDB0000265 concentration id 59369	Association	Human Urine	7256725	details
Hypothyroidism		This associated disease is originally imported from HMDB metabolite HMDB0000265 concentration id 59370	Association	Human Urine	7256725	details

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Proteobacteria	1	Human	Unknown

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified								HMDB		details
Human	Detected and Quantified	0.00169				Adult (>18 years old)	Female	Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency	HMDB	7951484	details
Human	Detected and Quantified	0.0014	0.0004			Adolescent (13-18 years old)	Female	Anorexia nervosa	HMDB	10197568	details
Human	Detected and Quantified	0.00075	0.00033			Adult (>18 years old)	Both	Hyperthyroidism	HMDB	7256725	details
Human	Detected and Quantified	0.000014	0.000015			Adult (>18 years old)	Both	Hypothyroidism	HMDB	7256725	details
Human	Detected and Quantified	0.0000041				Adult (>18 years old)	Female	Proprotein Convertase 1/3 Deficiency	HMDB	7477119	details
Human	Detected and Quantified			0.0	1.0	Adult (>18 years old)	Both	Normal	HMDB	15179829	details
Human	Detected and Quantified			0.0000031	0.0000077	Adult (>18 years old)	Not Specified	Normal	HMDB	7477119	details
Human	Detected and Quantified	0.002	0.0006			Adolescent (13-18 years old)	Female	Normal	HMDB	10197568	details
Human	Detected and Quantified	0.0029	0.00019			Children (1-13 years old)	Both	Normal	HMDB	10731506	details
Human	Detected and Quantified			0.0000038	0.0000060	Adult (>18 years old)	Both	Normal	HMDB	K&S Clinical Diagnostics (http://www.ksdiagnostics.com)	details
Human	Detected and Quantified			0.000013	0.000028	Adult (>18 years old)	Both	Normal	HMDB	K&S Clinical Diagnostics (http://www.ksdiagnostics.com)	details
Human Adipose Tissue	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Adrenal Gland	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Epidermis	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Fibroblasts	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Intestine	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Neuron	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Placenta	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Platelet	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Skeletal Muscle	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Testis	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Thyroid Gland	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Holt PJ: In vitro responses of the epidermis to triiodothyronine. J Invest Dermatol. 1978 Sep;71(3):202-4. doi: 10.1111/1523-1747.ep12547158. [PubMed:690484 ]
Gledhill RF, Dessein PH, Van der Merwe CA: Treatment of Raynaud's phenomenon with triiodothyronine corrects co-existent autonomic dysfunction: preliminary findings. Postgrad Med J. 1992 Apr;68(798):263-7. doi: 10.1136/pgmj.68.798.263. [PubMed:1409189 ]
Iwao H, Abe Y: [Expression of the renin and angiotensinogen genes]. Nihon Yakurigaku Zasshi. 1991 Jan;97(1):1-11. doi: 10.1254/fpj.97.1_1. [PubMed:2045011 ]
Himms-Hagen J: Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J. 1990 Aug;4(11):2890-8. [PubMed:2199286 ]
Calvo R, Obregon MJ, Ruiz de Ona C, Escobar del Rey F, Morreale de Escobar G: Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain. J Clin Invest. 1990 Sep;86(3):889-99. doi: 10.1172/JCI114790. [PubMed:2394838 ]
Dutkiewicz S, Witeska A, Nauman A: The deiodination of thyroxine to triiodothyronine in the testes of patients with prostate cancer. Int Urol Nephrol. 1995;27(1):81-5. doi: 10.1007/BF02575224. [PubMed:7615374 ]
Llewellyn L, Ramsurn VP, Wigham T, Sweeney GE, Power DM: Cloning, characterisation and expression of the apolipoprotein A-I gene in the sea bream (Sparus aurata). Biochim Biophys Acta. 1998 Nov 8;1442(2-3):399-404. doi: 10.1016/s0167-4781(98)00171-7. [PubMed:9804999 ]
Zimmermann-Belsing T, Dreyer M, Holst JJ, Feldt-Rasmussen U: The relationship between the serum leptin concentrations of thyrotoxic patients during treatment and their total fat mass is different from that of normal subjects. Clin Endocrinol (Oxf). 1998 Nov;49(5):589-95. doi: 10.1046/j.1365-2265.1998.00627.x. [PubMed:10197073 ]
Kassem M, Brixen K, Mosekilde L, Blum WF, Flyvbjerg A: Effects of growth hormone treatment on serum levels of insulin-like growth factors (IGFs) and IGF binding proteins 1-4 in postmenopausal women. Clin Endocrinol (Oxf). 1998 Dec;49(6):747-56. doi: 10.1046/j.1365-2265.1998.00606.x. [PubMed:10209562 ]
Urcelay E, Jareno MA, Menaya J, Parrilla R, Ayuso MS, Martin-Requero A: Cloning and functional characterization of the 5' regulatory region of the human mitochondrial glycerol-3-phosphate dehydrogenase gene. Lack of 3,5,3'-triiodothyronine responsiveness in adipose tissue. Eur J Biochem. 2000 Dec;267(24):7209-17. doi: 10.1046/j.1432-1327.2000.01832.x. [PubMed:11106433 ]
Mizuma H, Murakami M, Mori M: Thyroid hormone activation in human vascular smooth muscle cells: expression of type II iodothyronine deiodinase. Circ Res. 2001 Feb 16;88(3):313-8. doi: 10.1161/01.res.88.3.313. [PubMed:11179199 ]
Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL, Shulman GI: Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest. 2001 Sep;108(5):733-7. doi: 10.1172/JCI11775. [PubMed:11544279 ]
Stalenheim EG: Long-term validity of biological markers of psychopathy and criminal recidivism: follow-up 6-8 years after forensic psychiatric investigation. Psychiatry Res. 2004 Jan 1;121(3):281-91. doi: 10.1016/j.psychres.2003.07.002. [PubMed:14675747 ]
Gil'miiarova FN, Pervova IuV, Radomskaia VM, Gergel' NI, Tarasova SV: [Levels of unified metabolites and thyroid hormones in blood and oral fluid of children with minimal brain dysfunction]. Biomed Khim. 2004 Mar-Apr;50(2):204-10. [PubMed:15179829 ]
Haas MJ, Fishman M, Mreyoud A, Mooradian AD: Thyroid hormone responsive protein (THRP) mediates thyroid hormone-induced cytotoxicity in primary neuronal cultures. Exp Brain Res. 2005 Jan;160(4):424-32. doi: 10.1007/s00221-004-2027-6. Epub 2004 Oct 15. [PubMed:15490139 ]
Escobar-Morreale HF, Botella-Carretero JI, Gomez-Bueno M, Galan JM, Barrios V, Sancho J: Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann Intern Med. 2005 Mar 15;142(6):412-24. doi: 10.7326/0003-4819-142-6-200503150-00007. [PubMed:15767619 ]
Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE: Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. Am J Hum Genet. 2005 Jul;77(1):41-53. doi: 10.1086/431313. Epub 2005 May 11. [PubMed:15889350 ]
Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E, Leibel RL: Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest. 2005 Dec;115(12):3579-86. doi: 10.1172/JCI25977. [PubMed:16322796 ]

Showing metabocard for Liothyronine (MMDBc0031978)

MOL for #<Metabolite:0x000055b76dcc51d0>

3D MOL for #<Metabolite:0x000055b76dcc51d0>

3D SDF for #<Metabolite:0x000055b76dcc51d0>

3D-SDF for #<Metabolite:0x000055b76dcc51d0>

PDB for #<Metabolite:0x000055b76dcc51d0>

3D PDB for #<Metabolite:0x000055b76dcc51d0>

SMILES for #<Metabolite:0x000055b76dcc51d0>

INCHI for #<Metabolite:0x000055b76dcc51d0>

Structure for #<Metabolite:0x000055b76dcc51d0>

3D Structure for #<Metabolite:0x000055b76dcc51d0>