| Record Information |
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| Version | 1.0 |
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| Status | Detected and Quantified |
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| Creation Date | 2021-11-18 01:58:33 UTC |
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| Update Date | 2022-08-31 18:27:30 UTC |
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| MiMeDB ID | MMDBc0032011 |
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| Metabolite Identification |
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| Common Name | 3,5-Diiodo-L-tyrosine |
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| Description | NULL |
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| Structure | |
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| Synonyms | Not Available |
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| Chemical Formula | C9H9I2NO3 |
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| Average Molecular Weight | 432.9816 |
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| Monoisotopic Molecular Weight | 432.867179999 |
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| IUPAC Name | Not Available |
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| Traditional Name | Not Available |
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| CAS Registry Number | Not Available |
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| SMILES | Not Available |
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| InChI Identifier | InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1 |
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| InChI Key | NYPYHUZRZVSYKL-ZETCQYMHSA-N |
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| Chemical Taxonomy |
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| Functional Ontology |
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Not Available | | Physical Properties |
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| State | Expected Solid |
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| Predicted Properties | Not Available |
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| Spectra |
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| Not Available |
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| Biological Properties |
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| Cellular Locations | |
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| Biospecimen Locations | |
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| Tissue Locations | Not Available |
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| Associated OMIM IDs | - 114500 (Colorectal cancer)
- 610247 (Eosinophilic esophagitis)
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| Human Proteins and Enzymes |
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| Proteins | #<MetaboliteProteinLink:0x000055b76dd58ed0> |
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| Human Pathways |
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| Pathways | |
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| Metabolic Reactions |
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| | Reaction ID | Precursor | Product | Enzyme | Reaction Type | Data Source | Reference |
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| Health Effects and Bioactivity |
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| | Health Outcome/Bioactivity | Metabolite Response/Effect | Related Health Condition | Evidence Type | Measured in Matrix | Data Source | Reference | |
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| Chronic kidney disease | Slight Increase | This associated disease is originally imported from HMDB metabolite HMDB0003474 concentration id 59253 | Association | Human Urine | | 3098453 | details | | Hyperthyroidism | | This associated disease is originally imported from HMDB metabolite HMDB0003474 concentration id 17803 | Association | Human Blood | | 11344555 | details |
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| Microbial Sources |
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| | Kingdom | Phylum | Total species | Hosts and Body Sites | Microbial Links |
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| Proteobacteria | 1 | Human | Unknown |
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| Exposure Sources |
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| | Source Type | Source Sub-type | Species | Data Source | Reference | Details |
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| Host Biospecimen and Location |
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| | Host and Biospecimen | Status | Mean | Std | Min | Max | Units | Age | Sex | Health Condition | Data Source | Reference | |
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| Human Feces | Detected but not Quantified | | | | | | | | | HMDB | | details | | Human | Detected and Quantified | 0.00013 | 0.000098 | | | | Adult (>18 years old) | Both | Chronic renal disease | HMDB | 3098453 | details | | Human | Detected and Quantified | 0.0036 | | 0.0010 | 0.0134 | | Adult (>18 years old) | Both | Hyperthyroidism | HMDB | 11344555 | details | | Human | Detected and Quantified | 0.000049 | 0.000027 | | | | Adult (>18 years old) | Both | Normal | HMDB | 3098453 | details | | Human | Detected and Quantified | 0.0036 | | 0.0014 | 0.0099 | | Adult (>18 years old) | Both | Normal | HMDB | 11344555 | details |
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| External Links |
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| HMDB ID | Not Available |
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| DrugBank ID | Not Available |
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| Phenol Explorer Compound ID | Not Available |
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| FooDB ID | Not Available |
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| KNApSAcK ID | Not Available |
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| Chemspider ID | Not Available |
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| KEGG Compound ID | Not Available |
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| BioCyc ID | Not Available |
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| BiGG ID | Not Available |
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| Wikipedia Link | Not Available |
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| METLIN ID | Not Available |
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| PubChem Compound | Not Available |
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| PDB ID | Not Available |
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| ChEBI ID | Not Available |
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| Food Biomarker Ontology | Not Available |
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| References |
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| Synthesis Reference | Not Available |
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| General References | - Bismuth J, Castay M, Lissitzky S: Binding of 3,5-diiodotyrosine to serum proteins. Clin Chim Acta. 1976 Jun 15;69(3):417-22. doi: 10.1016/0009-8981(76)90113-3. [PubMed:59643 ]
- Ismail-Beigi F, Rahimifar M: A variant of iodotyrosine-dehalogenase deficiency. J Clin Endocrinol Metab. 1977 Mar;44(3):499-506. doi: 10.1210/jcem-44-3-499. [PubMed:838849 ]
- Tompkins RK, Croke JC: Bile acids inhibit pepsin activity against a refined substrate. Am J Surg. 1980 Feb;139(2):237-9. doi: 10.1016/0002-9610(80)90262-7. [PubMed:6766680 ]
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