MiMeDB: Showing metabocard for Ubiquinone-10 (MMDBc0032879)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-18 22:55:52 UTC

Update Date

2022-08-31 21:44:55 UTC

MiMeDB ID

MMDBc0032879

Metabolite Identification

Common Name

Ubiquinone-10

Description

Ubiquinone-10 is a member of the chemical class known as Polyprenylbenzoquinones. These are compounds containing a polyisoprene chain attached to a quinone at the second ring position. Ubiquione-10 has 10 isoprene units. Normally in Pseudomonas aeruginosa

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₅₉H₉₀O₄

Average Molecular Weight

863.3435

Monoisotopic Molecular Weight

862.683911368

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

303-98-0

SMILES

Not Available

InChI Identifier

InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI Key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Membrane
Mitochondria

Biospecimen Locations

Blood
Brain
Kidney
Leukocyte
Liver
Skeletal Muscle

Tissue Locations

Brain
Kidney
Leukocyte
Liver
Skeletal Muscle

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76e15deb8>

Human Pathways

Pathways

Name	SMPDB/PathBank
Immunometabolism Pathway (Bacterial Activation)
Immunometabolism Pathway (Viral Activation)
Viral Sepsis

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
	Proteobacteria	1	Human	Unknown

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details
Plant	Fruit	Piper nigrum	FooDB	31437929	details
Plant	Leaves	Brassica oleracea l. var. capitata l. f. alba dc.	FooDB	31437929	details
Plant	Leaves	Brassica oleracea var. capitata	FooDB	31437929	details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human	Detected and Quantified	0.040	0.014			Adult (>18 years old)	Male	Normal	HMDB	16583456	details
Human	Detected and Quantified	0.056	0.023			Adult (>18 years old)	Male	Normal	HMDB	16583456	details
Human	Detected and Quantified	4.31	0.42			Adult (>18 years old)	Both	Normal	HMDB	20671299	details
Human	Detected and Quantified	0.65	0.18			Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human	Detected and Quantified	0.85		0.46	1.33	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human	Detected and Quantified	1.17	0.12			Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.	details
Human Brain	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Kidney	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Leukocyte	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Liver	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details
Human Skeletal Muscle	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597	details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Folkers K, Hanioka T, Xia LJ, McRee JT Jr, Langsjoen P: Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex. Biochem Biophys Res Commun. 1991 Apr 30;176(2):786-91. doi: 10.1016/s0006-291x(05)80254-2. [PubMed:1673841 ]
Zierz S, von Wersebe O, Bleistein J, Jerusalem F: Exogenous coenzyme Q (coq) fails to increase coq in skeletal muscle of two patients with mitochondrial myopathies. J Neurol Sci. 1990 Mar;95(3):283-90. doi: 10.1016/0022-510x(90)90075-x. [PubMed:2358821 ]
Zierz S, Jahns G, Jerusalem F: Coenzyme Q in serum and muscle of 5 patients with Kearns-Sayre syndrome and 12 patients with ophthalmoplegia plus. J Neurol. 1989 Feb;236(2):97-101. doi: 10.1007/BF00314404. [PubMed:2709060 ]
Ogasahara S, Engel AG, Frens D, Mack D: Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy. Proc Natl Acad Sci U S A. 1989 Apr;86(7):2379-82. doi: 10.1073/pnas.86.7.2379. [PubMed:2928337 ]
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Mancini A, Conte B, De Marinis L, Hallgass ME, Pozza D, Oradei A, Littarru GP: Coenzyme Q10 levels in human seminal fluid: diagnostic and clinical implications. Mol Aspects Med. 1994;15 Suppl:s249-55. doi: 10.1016/0098-2997(94)90035-3. [PubMed:7752837 ]
Appelkvist EL, Edlund C, Low P, Schedin S, Kalen A, Dallner G: Effects of inhibitors of hydroxymethylglutaryl coenzyme A reductase on coenzyme Q and dolichol biosynthesis. Clin Investig. 1993;71(8 Suppl):S97-102. doi: 10.1007/BF00226848. [PubMed:8241713 ]
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Miyake Y, Shouzu A, Nishikawa M, Yonemoto T, Shimizu H, Omoto S, Hayakawa T, Inada M: Effect of treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients. Arzneimittelforschung. 1999 Apr;49(4):324-9. doi: 10.1055/s-0031-1300422. [PubMed:10337451 ]
De Luca C, Filosa A, Grandinetti M, Maggio F, Lamba M, Passi S: Blood antioxidant status and urinary levels of catecholamine metabolites in beta-thalassemia. Free Radic Res. 1999 Jun;30(6):453-62. doi: 10.1080/10715769900300491. [PubMed:10400457 ]
Tomasetti M, Alleva R, Solenghi MD, Littarru GP: Distribution of antioxidants among blood components and lipoproteins: significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis. Biofactors. 1999;9(2-4):231-40. doi: 10.1002/biof.5520090218. [PubMed:10416035 ]
Siciliano G, Mancuso M, Tedeschi D, Manca ML, Renna MR, Lombardi V, Rocchi A, Martelli F, Murri L: Coenzyme Q10, exercise lactate and CTG trinucleotide expansion in myotonic dystrophy. Brain Res Bull. 2001 Oct-Nov 1;56(3-4):405-10. doi: 10.1016/s0361-9230(01)00653-0. [PubMed:11719279 ]
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Hanisch F, Zierz S: Only transient increase of serum CoQ subset 10 during long-term CoQ10 therapy in mitochondrial ophthalmoplegia. Eur J Med Res. 2003 Nov 12;8(11):485-91. [PubMed:14644702 ]
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Showing metabocard for Ubiquinone-10 (MMDBc0032879)

MOL for #<Metabolite:0x000055b76dc13138>

3D MOL for #<Metabolite:0x000055b76dc13138>

3D SDF for #<Metabolite:0x000055b76dc13138>

3D-SDF for #<Metabolite:0x000055b76dc13138>

PDB for #<Metabolite:0x000055b76dc13138>

3D PDB for #<Metabolite:0x000055b76dc13138>

SMILES for #<Metabolite:0x000055b76dc13138>

INCHI for #<Metabolite:0x000055b76dc13138>

Structure for #<Metabolite:0x000055b76dc13138>

3D Structure for #<Metabolite:0x000055b76dc13138>