MiMeDB: Showing metabocard for 1D-Myo-inositol 1,4,5,6-tetrakisphosphate (MMDBc0032901)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-19 04:20:44 UTC

Update Date

2022-08-31 21:45:24 UTC

MiMeDB ID

MMDBc0032901

Metabolite Identification

Common Name

1D-Myo-inositol 1,4,5,6-tetrakisphosphate

Description

Inositol phosphates are a family of water-soluble intracellular signalling molecules derived from membrane inositol phospholipids. They undergo a variety of complex interconversion pathways, and their levels are dynamically regulated within the cytosol in response to a variety of agonists. Their biological actions can be quite specific to particular inositol phosphates. D-myo-Inositol 3,4,5,6-tetrakisphosphate, also known as Ins(1,4,5,6)P4 is phosphorylated by inositolphosphate-multikinase (IMPK). Ins(1,4,5,6)P4 has been shown to regulate Cl- transport, to be a phosphoinositide 3-kinase antagonist, and to bind tightly to some pleckstrin homology domains. It may also contribute to transcriptional regulation (PMID: 16376887 , 10720331 , 8809047 , 9405634 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₆H₁₆O₁₈P₄

Average Molecular Weight

500.0755

Monoisotopic Molecular Weight

499.928709756

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

121010-58-0

SMILES

Not Available

InChI Identifier

InChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m1/s1

InChI Key

MRVYFOANPDTYBY-YORTWTKJSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Feces

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Proteins

#<MetaboliteProteinLink:0x000055b76e1e2118>

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Related Health Condition	Evidence Type	Measured in Matrix	Data Source	Reference

Microbial Sources

Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Fungi	Ascomycota	3	Human Feces	Unknown;

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference	Details

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB		details

External Links

Not Available

References

Synthesis Reference

Not Available

General References

Takeuchi H, Kanematsu T, Misumi Y, Yaakob HB, Yagisawa H, Ikehara Y, Watanabe Y, Tan Z, Shears SB, Hirata M: Localization of a high-affinity inositol 1,4,5-trisphosphate/inositol 1,4,5,6-tetrakisphosphate binding domain to the pleckstrin homology module of a new 130 kDa protein: characterization of the determinants of structural specificity. Biochem J. 1996 Sep 1;318 ( Pt 2):561-8. doi: 10.1042/bj3180561. [PubMed:8809047 ]
Eckmann L, Rudolf MT, Ptasznik A, Schultz C, Jiang T, Wolfson N, Tsien R, Fierer J, Shears SB, Kagnoff MF, Traynor-Kaplan AE: D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14456-60. doi: 10.1073/pnas.94.26.14456. [PubMed:9405634 ]
Odom AR, Stahlberg A, Wente SR, York JD: A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science. 2000 Mar 17;287(5460):2026-9. doi: 10.1126/science.287.5460.2026. [PubMed:10720331 ]
Riley AM, Deleu S, Qian X, Mitchell J, Chung SK, Adelt S, Vogel G, Potter BV, Shears SB: On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate. FEBS Lett. 2006 Jan 9;580(1):324-30. doi: 10.1016/j.febslet.2005.12.016. Epub 2005 Dec 19. [PubMed:16376887 ]

Showing metabocard for 1D-Myo-inositol 1,4,5,6-tetrakisphosphate (MMDBc0032901)

MOL for #<Metabolite:0x000055b76a62a030>

3D MOL for #<Metabolite:0x000055b76a62a030>

3D SDF for #<Metabolite:0x000055b76a62a030>

3D-SDF for #<Metabolite:0x000055b76a62a030>

PDB for #<Metabolite:0x000055b76a62a030>

3D PDB for #<Metabolite:0x000055b76a62a030>

SMILES for #<Metabolite:0x000055b76a62a030>

INCHI for #<Metabolite:0x000055b76a62a030>

Structure for #<Metabolite:0x000055b76a62a030>

3D Structure for #<Metabolite:0x000055b76a62a030>