Showing metabocard for 1-MLCL(0:0/10:0/18:0/24:0) (MMDBc0043533)
Record Information
Version
1.0
Status
Detected and Quantified
Creation Date
2021-11-19 12:18:25 UTC
Update Date
2022-09-01 00:05:42 UTC
MiMeDB ID
MMDBc0043533
Metabolite Identification
Common Name
1-MLCL(0:0/10:0/18:0/24:0)
Description
1-MLCL(0:0/10:0/18:0/24:0) is a monolysocardiolipin (MLCL). Monolysocardiolipins have three fatty acid tails, instead of the usual two. 1-MLCL(0:0/10:0/18:0/24:0) contains one chain of at the C1 position, one chain of decanoic acid at the C2 position, one chain of octadecanoic acid at the C3 position, one chain of tetracosanoic acid at the C4 position. MLCL is present in eukaryotes as part of the metabolic cycle of mitochondrial lipids. Removal of one acyl chain from a cardiolipin results in generation of monolysocardiolipin (MLCL). MLCL has been used as an inter­mediate in the synthesis of spin-labeled CL to study the interaction of CL with mitochondrial enzymes. Because a role for MLCL has been suggested in apoptosis, this molecule has been used to study its interaction with various enzymes involved in lipid remodeling and apoptosis. There are two species of monolysocardiolipins, 1-MLCL which is missing a fatty acid in position R1 the and 2-MLCL which is missing a fatty acid in position R4.
Wishart DS, Li C, Marcu A, Badran H, Pon A, Budinski Z, Patron J, Lipton D, Cao X, Oler E, Li K, Paccoud M, Hong C, Guo AC, Chan C, Wei W, Ramirez-Gaona M: PathBank: a comprehensive pathway database for model organisms. Nucleic Acids Res. 2020 Jan 8;48(D1):D470-D478. doi: 10.1093/nar/gkz861. [PubMed:31602464 ]
