Showing metabocard for Estrone (MMDBc0047903)

Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-23 23:10:07 UTC
Update Date2022-09-01 02:00:50 UTC
MiMeDB IDMMDBc0047903
Metabolite Identification
Common NameEstrone
DescriptionEstrone is a major mammalian estrogen. The conversion of the natural C19 steroids, testosterone and androstenedione into estrone is dependent on a complex key reaction catalyzed by the cytochrome P450 aromatase (EC 1.14.14.1, unspecific monooxygenase), which is expressed in many tissues of the adult human (e.g. ovary, fat tissue), but not in the liver. The ovaries after menopause continue to produce androstenedione and testosterone in significant amounts and these androgens are converted in fat, muscle, and skin into estrone. When women between the ages of 45 and 64 years have prophylactic oophorectomy (when hysterectomy is performed for benign disease to prevent the development of ovarian cancer), evidence suggests that oophorectomy increases the subsequent risk of coronary heart disease (CHD) and osteoporosis. Whereas 14,000 women die of ovarian cancer every year nearly 490,000 women die of heart disease and 48,000 women die within 1 year after hip fracture. Therefore, the decision to perform prophylactic oophorectomy should be approached with great caution for the majority of women who are at low risk of developing ovarian cancer. Steroid sulfatase (EC 3.1.6.2, STS) hydrolyzes steroid sulfates, such as estrone sulfate to estrone which can be converted to steroids with potent estrogenic properties, that is, estradiol; STS activity is much higher in breast tumors and high levels of STS mRNA expression in tumors are associated with a poor prognosis. The biological roles of estrogens in tumorigenesis are certainly different between the endometrium and breast, although both are considered "estrogen-dependent tissues". 17beta-hydroxysteroid dehydrogenases (EC 1.1.1.62, 17-HSDs) are enzymes involved in the formation of active sex steroids. estrone is interconverted by two enzymes 17-HSD types. Type 1 converts estrone to estradiol and Type 2 catalyzes the reverse reaction. (PMID: 17653961 , 17513923 , 17470679 , 17464097 ).
Structure
MOLSDFPDBSMILESInChI

MOL for #<Metabolite:0x000055b76be15258>

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3D MOL for #<Metabolite:0x000055b76be15258>
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3D SDF for #<Metabolite:0x000055b76be15258>
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3D-SDF for #<Metabolite:0x000055b76be15258>
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PDB for #<Metabolite:0x000055b76be15258>
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3D PDB for #<Metabolite:0x000055b76be15258>
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SMILES for #<Metabolite:0x000055b76be15258>
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INCHI for #<Metabolite:0x000055b76be15258>
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SynonymsNot Available
Chemical FormulaC18H22O2
Average Molecular Weight270.3661
Monoisotopic Molecular Weight270.161979948
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number53-16-7
SMILESNot Available
InChI Identifier
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
InChI KeyDNXHEGUUPJUMQT-CBZIJGRNSA-N