Record Information Version 1.0 Status Detected and Quantified Creation Date 2021-11-23 23:15:42 UTC Update Date 2022-09-01 02:01:41 UTC MiMeDB ID MMDBc0047923 Metabolite Identification Common Name 5,6-Dihydroxyindole-2-carboxylic acid Description 5,6-Dihydroxyindole-2-carboxylic acid is an intermediate in the metabolism of Tyrosine. It is a substrate for Dopachrome tautomerase. Structure Synonyms Not Available Chemical Formula C9 H7 NO4 Average Molecular Weight 193.1562 Monoisotopic Molecular Weight 193.037507717 IUPAC Name Not Available Traditional Name Not Available CAS Registry Number 4790-08-3 SMILES Not Available InChI Identifier InChI=1S/C9H7NO4/c11-7-2-4-1-6(9(13)14)10-5(4)3-8(7)12/h1-3,10-12H,(H,13,14)
InChI Key YFTGOBNOJKXZJC-UHFFFAOYSA-N Chemical Taxonomy Functional Ontology Not Available Physical Properties State Solid Predicted Properties Not Available Spectra Not Available Biological Properties Cellular Locations Biospecimen Locations Tissue Locations Not Available Associated OMIM IDs 114500 (Colorectal cancer)610247 (Eosinophilic esophagitis)Human Proteins and Enzymes Proteins #<MetaboliteProteinLink:0x000055b76befc450> Human Pathways Pathways Name SMPDB/PathBank Eumelanin Biosynthesis
Metabolic Reactions Reaction ID Precursor Product Enzyme Reaction Type Data Source Reference
Health Effects and Bioactivity Health Outcome/Bioactivity Metabolite Response/Effect Related Health Condition Evidence Type Measured in Matrix Data Source Reference
Microbial Sources Kingdom Phylum Total species Hosts and Body Sites Microbial Links Firmicutes 2 Human Feces Metabolic reconstruction Proteobacteria 1 Human Feces Metabolic reconstruction
Exposure Sources Source Type Source Sub-type Species Data Source Reference Details
Host Biospecimen and Location Host and Biospecimen Status Mean Std Min Max Units Age Sex Health Condition Data Source Reference Human Feces Detected but not Quantified HMDB details
External Links External Links Not Available References Synthesis Reference Not Available General References Yamada K, Walsh N, Hara H, Jimbow K, Chen H, Ito S: Measurement of eumelanin precursor metabolites in the urine as a new marker for melanoma metastases. Arch Dermatol. 1992 Apr;128(4):491-4. [PubMed:1580656 ] Hansson C: Some indolic compounds as markers of the melanocyte activity. Acta Derm Venereol Suppl (Stockh). 1988;138:1-60. [PubMed:3176811 ]
