MiMeDB: Showing metabocard for 5,6-Dihydroxyindole-2-carboxylic acid (MMDBc0047923)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-23 23:15:42 UTC

Update Date

2022-09-01 02:01:41 UTC

Metabolite ID

MMDBc0047923

Metabolite Identification

Common Name

5,6-Dihydroxyindole-2-carboxylic acid

Description

5,6-Dihydroxyindole-2-carboxylic acid is an intermediate in the metabolism of Tyrosine. It is a substrate for Dopachrome tautomerase.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₉H₇NO₄

Average Mass

193.1562

Monoisotopic Mass

193.037507717

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

4790-08-3

SMILES

Not Available

InChI Identifier

InChI=1S/C9H7NO4/c11-7-2-4-1-6(9(13)14)10-5(4)3-8(7)12/h1-3,10-12H,(H,13,14)

InChI Key

YFTGOBNOJKXZJC-UHFFFAOYSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Cytoplasm
Membrane

Biospecimen Locations

Feces

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191773	Macrophage migration inhibitory factor	Enzyme	P14174	Homo_sapiens
MMDBp0191879	L-dopachrome tautomerase	Unknown	P40126	Homo_sapiens
MMDBp0193432	5,6-dihydroxyindole-2-carboxylic acid oxidase	Unknown	P17643	Homo_sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank
Eumelanin Biosynthesis

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Firmicutes	2	Human feces	Metabolic reconstruction
Bacteria	Proteobacteria	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB

External Links

Not Available

General References

Yamada K, Walsh N, Hara H, Jimbow K, Chen H, Ito S: Measurement of eumelanin precursor metabolites in the urine as a new marker for melanoma metastases. Arch Dermatol. 1992 Apr;128(4):491-4. [PubMed:1580656 ]
Hansson C: Some indolic compounds as markers of the melanocyte activity. Acta Derm Venereol Suppl (Stockh). 1988;138:1-60. [PubMed:3176811 ]

Showing metabocard for 5,6-Dihydroxyindole-2-carboxylic acid (MMDBc0047923)

MOL for #<Metabolite:0x00007f1240f67008>

3D MOL for #<Metabolite:0x00007f1240f67008>

3D SDF for #<Metabolite:0x00007f1240f67008>

3D-SDF for #<Metabolite:0x00007f1240f67008>

PDB for #<Metabolite:0x00007f1240f67008>

3D PDB for #<Metabolite:0x00007f1240f67008>

SMILES for #<Metabolite:0x00007f1240f67008>

INCHI for #<Metabolite:0x00007f1240f67008>

Structure for #<Metabolite:0x00007f1240f67008>

3D Structure for #<Metabolite:0x00007f1240f67008>