MiMeDB: Showing metabocard for D-threitol (MMDBc0054440)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2022-06-05 23:12:27 UTC

Update Date

2022-08-12 20:09:00 UTC

Metabolite ID

MMDBc0054440

Metabolite Identification

Common Name

D-threitol

Description

D-Threitol can be regarded as the main end product of D-xylose metabolism in hummans. Threitol is a C4-polyol (tetritol); the total C4-polyol concentration of threitol decreases with age. Several inborn errors of metabolism with abnormal polyol concentrations in body fluids are known to date (such as pentosuria and galactosemia). Most of these defects can be diagnosed by the assessment of urinary concentrations of polyols. Several studies have revealed that urinary levels of some polyols may vary in diseases associated with carbohydrate metabolism derangements such as diabetes mellitus and uremia. The abnormal occurrence of various polyols in diseases with a specific enzyme deficiency such as pentosuria and galactosemia has also been reported (PMID:908147 , 16435188 , 14988808 ). Moreover, D-Threitol is found to be associated with ribose-5-phosphate isomerase deficiency, which is also an inborn error of metabolism. Threitol in the urine is a biomarker for the consumption of apples and other fruits.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₄H₁₀O₄

Average Mass

122.1198

Monoisotopic Mass

122.057908808

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2/t3-,4-/m1/s1

InChI Key

UNXHWFMMPAWVPI-QWWZWVQMSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Blood
Cerebrospinal Fluid (CSF)
Feces
Urine

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Ribose-5-phosphate isomerase deficiency	Increased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	14988808
Ribose-5-phosphate isomerase deficiency		Association	Human Urine	HMDB	14988808
Ribose-5-phosphate isomerase deficiency		Association	Human Blood	HMDB	14988808
Uremia	Slight Increase	Association	Human Blood	HMDB	12675874

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Actinobacteria	1	Human
Eukaryota/Fungi	Basidiomycota	2	Human feces

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Age	Sex	Health Condition	Data Source	Reference
Human	Detected and Quantified			29	67	Adolescent (13-18 years old)	Both	Ribose-5-Phosphate Isomerase Deficiency	HMDB	14988808
Human	Detected and Quantified	55.0		38.0	81.0	Adolescent (13-18 years old)	Both	Ribose-5-Phosphate Isomerase Deficiency	HMDB	14988808
Human	Detected and Quantified	6.5		5.0	8.0	Adolescent (13-18 years old)	Both	Ribose-5-Phosphate Isomerase Deficiency	HMDB	14988808
Human	Detected and Quantified	8.115	7.541			Adult (>18 years old)	Both	Uremia	HMDB	12675874
Human	Detected and Quantified	<2.620				Adult (>18 years old)	Both	Normal	HMDB	12675874
Human	Detected and Quantified			0.0	7.0	Adolescent (13-18 years old)	Both	Normal	HMDB	14988808
Human	Detected and Quantified	19.3		5.3	32.7	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human	Detected and Quantified	2.5		0.0	5.0	Adolescent (13-18 years old)	Both	Normal	HMDB	14988808
Human	Detected and Quantified	45.0		7.0	83	Adolescent (13-18 years old)	Both	Normal	HMDB	14988808
Human	Detected and Quantified	10.0		5.6	15.0	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Feces	Detected but not Quantified					Infant (0-1 year old)	Both	Normal	HMDB	22411374
Human Feces	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	22944170
Human Urine	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	21736852
Human Blood	Detected but not Quantified					Adult (>18 years old)	Female	Normal	HMDB	27355821
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	25037050

External Links

Not Available

General References

Pitkanen E: The conversion of D-xylose into D-threitol in patients without liver disease and in patients with portal liver cirrhosis. Clin Chim Acta. 1977 Oct 1;80(1):49-54. doi: 10.1016/0009-8981(77)90262-5. [PubMed:908147 ]
Huck JH, Verhoeven NM, Struys EA, Salomons GS, Jakobs C, van der Knaap MS: Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy. Am J Hum Genet. 2004 Apr;74(4):745-51. doi: 10.1086/383204. Epub 2004 Feb 25. [PubMed:14988808 ]
Wamelink MM, Smith DE, Jakobs C, Verhoeven NM: Analysis of polyols in urine by liquid chromatography-tandem mass spectrometry: a useful tool for recognition of inborn errors affecting polyol metabolism. J Inherit Metab Dis. 2005;28(6):951-63. doi: 10.1007/s10545-005-0233-4. [PubMed:16435188 ]

Showing metabocard for D-threitol (MMDBc0054440)

MOL for #<Metabolite:0x00007f1240a334d8>

3D MOL for #<Metabolite:0x00007f1240a334d8>

3D SDF for #<Metabolite:0x00007f1240a334d8>

3D-SDF for #<Metabolite:0x00007f1240a334d8>

PDB for #<Metabolite:0x00007f1240a334d8>

3D PDB for #<Metabolite:0x00007f1240a334d8>

SMILES for #<Metabolite:0x00007f1240a334d8>

INCHI for #<Metabolite:0x00007f1240a334d8>

Structure for #<Metabolite:0x00007f1240a334d8>

3D Structure for #<Metabolite:0x00007f1240a334d8>