Showing metabocard for MLCL(0:0/10:0/20:0/28:0) (MMDBc0056633)
Record Information
Version
1.0
Status
Detected and Quantified
Creation Date
2022-07-07 21:56:22 UTC
Update Date
2022-08-14 03:03:27 UTC
MiMeDB ID
MMDBc0056633
Metabolite Identification
Common Name
MLCL(0:0/10:0/20:0/28:0)
Description
MLCL(0:0/10:0/20:0/28:0) is a monolysocardiolipin (MLCL). Monolysocardiolipins have three fatty acid tails, instead of the usual two. MLCL(0:0/10:0/20:0/28:0) contains no chain at the C1 position, one decanoyl chain at the C2 position, one eicosanoyl chain at the C3 position, one octacosanoyl chain at the C4 position. MLCL is present in eukaryotes as part of the metabolic cycle of mitochondrial lipids. Removal of one acyl chain from a cardiolipin results in generation of monolysocardiolipin (MLCL). MLCL has been used as an intermediate in the synthesis of spin-labeled CL to study the interaction of CL with mitochondrial enzymes. Because a role for MLCL has been suggested in apoptosis, this molecule has been used to study its interaction with various enzymes involved in lipid remodeling and apoptosis. There are two species of monolysocardiolipins, 1-MLCL which is missing a fatty acid in position R1 the and 2-MLCL which is missing a fatty acid in position R4.
Wishart DS, Li C, Marcu A, Badran H, Pon A, Budinski Z, Patron J, Lipton D, Cao X, Oler E, Li K, Paccoud M, Hong C, Guo AC, Chan C, Wei W, Ramirez-Gaona M: PathBank: a comprehensive pathway database for model organisms. Nucleic Acids Res. 2020 Jan 8;48(D1):D470-D478. doi: 10.1093/nar/gkz861. [PubMed:31602464 ]
