Showing metabocard for PGP(19:0cycw7/12:0(3-OH)) (MMDBc0057041)

Record Information
Version1.0
StatusDetected and Quantified
Creation Date2022-07-07 22:12:42 UTC
Update Date2022-08-14 03:40:30 UTC
Metabolite IDMMDBc0057041
Metabolite Identification
Common NamePGP(19:0cycw7/12:0(3-OH))
DescriptionPGP(19:0cycw7/12:0(3-OH)) is a phosphatidylglycerolphosphate or glycerophospholipid (PGP or GP). It is a glycerophospholipid in which a phosphoglycerol moiety occupies a glycerol substitution site followed by another phosphate moiety. As is the case with diacylglycerols, phosphatidylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PGP(19:0cycw7/12:0(3-OH)), in particular, consists of one heptadec-11-12-cyclo-anoyl chain at the C-1 position and one 3-hydroxydodecanoyl chain at the C-2 position. Phosphatidylglycerol is formed from phosphatidic acid by a sequence of enzymatic reactions that proceeds via the intermediate, cytidine diphosphate diacylglycerol (CDP-diacylglycerol). Bioynthesis proceeds by condensation of phosphatidic acid and cytidine triphosphate with elimination of pyrophosphate via the action of phosphatidate cytidyltransferase (or CDP-synthase). CDP-diacylglycerol then reacts with glycerol-3-phosphate via phosphatidylglycerophosphate synthase to form 3-sn-phosphatidyl-1'-sn-glycerol 3'-phosphoric acid, with the release of cytidine monophosphate (CMP). Finally, phosphatidylglycerol is formed by the action of specific phosphatases. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PGP also serves as a precursor for the synthesis of cardiolipin. PGP is synthesized from CDP-diacylglycerol and glycerol-3-phosphate. In E. coli, PGPs can be found in the cytoplasmic membrane.
Structure
MOLSDFPDBSMILESInChI

MOL for #<Metabolite:0x0000560be210e610>

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3D MOL for #<Metabolite:0x0000560be210e610>

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3D SDF for #<Metabolite:0x0000560be210e610>

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3D-SDF for #<Metabolite:0x0000560be210e610>

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PDB for #<Metabolite:0x0000560be210e610>

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3D PDB for #<Metabolite:0x0000560be210e610>

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SMILES for #<Metabolite:0x0000560be210e610>

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INCHI for #<Metabolite:0x0000560be210e610>

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SynonymsNot Available
Molecular FormulaC37H72O14P2
Average Mass802.917
Monoisotopic Mass802.439730994
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry NumberNot Available
SMILESNot Available
InChI Identifier
InChI=1S/C37H72O14P2/c1-3-5-7-9-11-15-19-23-33(38)26-37(41)51-35(30-50-53(45,46)49-28-34(39)27-48-52(42,43)44)29-47-36(40)24-20-16-13-10-12-14-18-22-32-25-31(32)21-17-8-6-4-2/h31-35,38-39H,3-30H2,1-2H3,(H,45,46)(H2,42,43,44)/t31?,32?,33?,34-,35+/m0/s1
InChI KeyVZZSSSVLOUPIQY-BISNVOBLSA-N